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    RIB4 lumazine synthase RIB4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854022, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RIB4
    Official Full Name
    lumazine synthase RIB4
    Primary source
    SGD:S000005503
    Locus tag
    YOL143C
    See related
    AllianceGenome:SGD:S000005503; FungiDB:YOL143C; VEuPathDB:YOL143C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 6,7-dimethyl-8-ribityllumazine synthase activity. Involved in riboflavin biosynthetic process. Located in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See RIB4 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (54595..55104, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ctr9p Neighboring gene Nop8p Neighboring gene exosome non-catalytic core subunit RRP40 Neighboring gene tRNA methyltransferase PPM2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The atomic structure of pentameric lumazine synthase from Saccharomyces cerevisiae at 1.85 A resolution reveals the binding mode of a phosphonate intermediate analogue. Meining W, et al. J Mol Biol, 2000 May 26. PMID 10860731
    2. Tunnel plasticity and quaternary structural integrity of a pentameric protein ring. Woycechowsky KJ, et al. Protein Sci, 2006 May. PMID 16641488, Free PMC Article
    3. (15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase. Yu TY, et al. Biochemistry, 2008 Dec 30. PMID 19117095, Free PMC Article
    4. Biosynthesis of riboflavin. Lumazine synthase of Escherichia coli. Mörtl S, et al. J Biol Chem, 1996 Dec 27. PMID 8969176
    5. Crystal structure of lumazine synthase from Mycobacterium tuberculosis as a target for rational drug design: binding mode of a new class of purinetrione inhibitors. Morgunova E, et al. Biochemistry, 2005 Mar 1. PMID 15723519

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. molecular dynamics simulations. The resulting models indicate mobility of the Lys92 side chain, which could facilitate the exchange of phosphate
      Title: (15)N{(31)P} REDOR NMR studies of the binding of phosphonate reaction intermediate analogues to Saccharomyces cerevisiae lumazine synthase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 6,7-dimethyl-8-ribityllumazine synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 6,7-dimethyl-8-ribityllumazine synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 6,7-dimethyl-8-ribityllumazine synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in riboflavin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in riboflavin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrial intermembrane space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    part_of riboflavin synthase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lumazine synthase RIB4
    NP_014498.1
    • Lumazine synthase (DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin; DMRL synthase stands for 6,7-dimethyl-8-ribityllumazine synthase

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      54595..55104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183397.1 → NP_014498.1  TPA: lumazine synthase RIB4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014498.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1S6, P50861, Q08286
      UniProtKB/TrEMBL
      A6ZN69, B3LIS4, C7GV18, C8ZHH4, G2WM95, N1NVR4
      Conserved Domains (1) summary
      TIGR00114
      Location:18 → 164
      lumazine-synth; 6,7-dimethyl-8-ribityllumazine synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50861.2

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