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    YCK2 serine/threonine protein kinase YCK2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855568, updated on 18-Sep-2024

    Summary

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    Official Symbol
    YCK2
    Official Full Name
    serine/threonine protein kinase YCK2
    Primary source
    SGD:S000005098
    Locus tag
    YNL154C
    See related
    AllianceGenome:SGD:S000005098; FungiDB:YNL154C; VEuPathDB:YNL154C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein serine/threonine kinase activity. Involved in several processes, including endocytosis; glucose mediated signaling pathway; and protein phosphorylation. Located in cellular bud neck; mating projection; and plasma membrane. Orthologous to human CSNK1G2 (casein kinase 1 gamma 2) and CSNK1G3 (casein kinase 1 gamma 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YCK2 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (343636..345276, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene Nsg2p Neighboring gene uncharacterized protein Neighboring gene Cuz1p Neighboring gene tubulin-binding prefolding complex subunit GIM3 Neighboring gene Inn1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Protein aggregation induced during glass bead lysis of yeast. Papanayotou I, et al. Yeast, 2010 Oct. PMID 20641011, Free PMC Article
    2. Akr1p-dependent palmitoylation of Yck2p yeast casein kinase 1 is necessary and sufficient for plasma membrane targeting. Babu P, et al. J Biol Chem, 2004 Jun 25. PMID 15105419
    3. Isolation and properties of YCK2, a Saccharomyces cerevisiae homolog of casein kinase-1. Vancura A, et al. Arch Biochem Biophys, 1993 Aug 15. PMID 8342955
    4. The yeast kinase Yck2 has a tripartite palmitoylation signal. Roth AF, et al. Mol Biol Cell, 2011 Aug 1. PMID 21653825, Free PMC Article
    5. A molecular genetics laboratory course applying bioinformatics and cell biology in the context of original research. Brame CJ, et al. CBE Life Sci Educ, 2008 Winter. PMID 19047427, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Compared with wild-type mitochondria, yck2 mitochondria revealed slower persulfide formation on Nfs1 consistent with a role of Yck2 in regulating mitochondrial cysteine desulfurase activity.
      Title: Cysteine desulfurase is regulated by phosphorylation of Nfs1 in yeast mitochondria.
    2. Data show that the pheromone-responsive G protein subunits beta/gamma (Gbetagamma; STE4/STE18) dimer promotes the polarization of the pheromone receptor by interacting with casein kinases 1 or 2 (Yck1/2) and locally inhibiting receptor phosphorylation.
      Title: Gβ promotes pheromone receptor polarization and yeast chemotropism by inhibiting receptor phosphorylation.
    3. Yck1p and Yck2p phosphorylate sites within the Sec2p Ypt32p/Sec15p binding region and in doing so promote binding of Sec2p to Sec15p and inhibit binding to Ypt32p.
      Title: The casein kinases Yck1p and Yck2p act in the secretory pathway, in part, by regulating the Rab exchange factor Sec2p.
    4. The yeast kinase Yck2 has a tripartite palmitoylation signal.
      Title: The yeast kinase Yck2 has a tripartite palmitoylation signal.
    5. there are overlapping kinetochore targets of CK2 and Aurora B kinases in mitotic regulation in yeast.
      Title: Overlapping kinetochore targets of CK2 and Aurora B kinases in mitotic regulation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity HDA PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glucose mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to glucose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in cellular bud neck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mating projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine protein kinase YCK2
    NP_014245.1
    • Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking, and glucose sensing; stabilized by Sod1p binding in the presence of glucose and oxygen, causing glucose repression of respiratory metabolism; involved in the phosphorylation and regulation of glucose sensor Rgt2p; YCK2 has a paralog, YCK1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      343636..345276 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182992.1 → NP_014245.1  TPA: serine/threonine protein kinase YCK2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014245.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W129, P23292
      UniProtKB/TrEMBL
      B3LP09, C7GXV4
      Conserved Domains (1) summary
      cd14127
      Location:75 → 351
      STKc_CK1_fungal; Catalytic domain of the Serine/Threonine protein kinase, Fungal Casein Kinase 1 homolog 1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23292.1

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