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    PEX27 Pex27p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854368, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PEX27
    Official Full Name
    Pex27p
    Primary source
    SGD:S000005719
    Locus tag
    YOR193W
    See related
    AllianceGenome:SGD:S000005719; FungiDB:YOR193W; VEuPathDB:YOR193W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in peroxisome organization. Acts upstream of or within peroxisome fission. Located in peroxisomal membrane. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PEX27 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (710446..711576)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene gag-pol fusion protein Neighboring gene gag protein Neighboring gene tRNA-Met Neighboring gene transcription initiation factor IIA large subunit Neighboring gene Slk19p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pex11-related proteins in peroxisome dynamics: a role for the novel peroxin Pex27p in controlling peroxisome size and number in Saccharomyces cerevisiae. Tam YY, et al. Mol Biol Cell, 2003 Oct. PMID 14517321, Free PMC Article
    2. Conserved function of pex11p and the novel pex25p and pex27p in peroxisome biogenesis. Rottensteiner H, et al. Mol Biol Cell, 2003 Oct. PMID 14517338, Free PMC Article
    3. A subtle interplay between three Pex11 proteins shapes de novo formation and fission of peroxisomes. Huber A, et al. Traffic, 2012 Jan. PMID 21951626, Free PMC Article
    4. The dynamin-related protein Vps1 and the peroxisomal membrane protein Pex27 function together during peroxisome fission. Ekal L, et al. J Cell Sci, 2023 Mar 15. PMID 36825558, Free PMC Article
    5. The peroxin Pex34p functions with the Pex11 family of peroxisomal divisional proteins to regulate the peroxisome population in yeast. Tower RJ, et al. Mol Biol Cell, 2011 May 15. PMID 21441307, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within peroxisome fission IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within peroxisome fission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome organization IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pex27p
    NP_014836.3
    • Peripheral peroxisomal membrane protein; required for Vps1-dependent peroxisome fission but not Dnm1-dependent fission; functions to control peroxisome size and number; interacts with Vps1p and Pex25p; accumulates at peroxisomal membrane constrictions; PEX27 has a paralog, PEX25, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      710446..711576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183612.3 → NP_014836.3  TPA: Pex27p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014836.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2Q2, Q08580
      UniProtKB/TrEMBL
      C7GWI6, N1NVU8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08580.1

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