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    TAH1 Tah1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850424, updated on 17-May-2024

    Summary

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    Gene symbol
    TAH1
    Gene description
    Tah1p
    Primary source
    FungiDB:YCR060W
    Locus tag
    YCR060W
    See related
    SGD:S000000656; AllianceGenome:SGD:S000000656; VEuPathDB:YCR060W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables chaperone binding activity. Involved in box C/D snoRNP assembly and protein folding. Located in cytoplasm and nucleus. Part of R2TP complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TAH1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (224399..224734)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene snoRNA-binding rRNA-processing protein PWP2 Neighboring gene Yih1p Neighboring gene Tvs1p Neighboring gene tRNA-Ser

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tah1 helix-swap dimerization prevents mixed Hsp90 co-chaperone complexes. Morgan RM, et al. Acta Crystallogr D Biol Crystallogr, 2015 May. PMID 25945584, Free PMC Article
    2. (1)H, (15)N and (13)C resonance assignments of the yeast Pih1 and Tah1 C-terminal domains complex. Manival X, et al. Biomol NMR Assign, 2015 Apr. PMID 24493341
    3. Structure of minimal tetratricopeptide repeat domain protein Tah1 reveals mechanism of its interaction with Pih1 and Hsp90. Jiménez B, et al. J Biol Chem, 2012 Feb 17. PMID 22179618, Free PMC Article
    4. Tah1, A Key Component of R2TP Complex that Regulates Assembly of snoRNP, is Involved in De Novo Generation and Maintenance of Yeast Prion [URE3]. Puri A, et al. J Mol Biol, 2021 Jun 25. PMID 33811921
    5. High-resolution structural analysis shows how Tah1 tethers Hsp90 to the R2TP complex. Back R, et al. Structure, 2013 Oct 8. PMID 24012479

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-folding chaperone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-folding chaperone binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in box C/D snoRNP assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein folding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein folding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of R2TP complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of R2TP complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tah1p
    NP_009986.1
    • Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1); R2TP complex interacts with Hsp90 (Hsp82p and Hsc82p) to mediate assembly of large protein complexes such as box C/D snoRNPs and RNA polymerase II; contains a single TPR domain with at least two TPR motifs; plays a role in determining prion variants

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      224399..224734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178771.1 → NP_009986.1  TPA: Tah1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009986.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR65, P25638
      UniProtKB/TrEMBL
      A0A6V8RV26, A6ZTN6, B3LUC0, C7GJS9, C8Z4E9, N1P623
      Conserved Domains (2) summary
      sd00006
      Location:8 → 32
      TPR; TPR repeat [structural motif]
      NF033920
      Location:11 → 68
      C39_PA2778_fam; PA2778 family cysteine peptidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25638.1

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