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    YIP1 transporter YIP1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853082, updated on 29-Jun-2024

    Summary

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    Gene symbol
    YIP1
    Gene description
    transporter YIP1
    Primary source
    FungiDB:YGR172C
    Locus tag
    YGR172C
    See related
    SGD:S000003404; AllianceGenome:SGD:S000003404; VEuPathDB:YGR172C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in endoplasmic reticulum to Golgi vesicle-mediated transport and vesicle fusion with Golgi apparatus. Located in COPII-coated ER to Golgi transport vesicle and endoplasmic reticulum membrane. Is integral component of Golgi membrane. Orthologous to several human genes including YIPF5 (Yip1 domain family member 5). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YIP1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (842845..843591, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene phosphatidylserine decarboxylase 2 Neighboring gene methionine--tRNA ligase MSM1 Neighboring gene Rbg2p Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis and properties of the yeast YIP1 family of Ypt-interacting proteins. Chen CZ, et al. Methods Enzymol, 2005. PMID 16473599
    2. Novel prosurvival function of Yip1A in human cervical cancer cells: constitutive activation of the IRE1 and PERK pathways of the unfolded protein response. Taguchi Y, et al. Cell Death Dis, 2017 Mar 30. PMID 28358375, Free PMC Article
    3. Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex. Heidtman M, et al. Mol Biol Cell, 2005 Apr. PMID 15659647, Free PMC Article
    4. The Yip1p.Yif1p complex is required for the fusion competence of endoplasmic reticulum-derived vesicles. Barrowman J, et al. J Biol Chem, 2003 May 30. PMID 12657649
    5. Perinuclear localization of chromatin facilitates transcriptional silencing. Andrulis ED, et al. Nature, 1998 Aug 6. PMID 9707122

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The present study is the first to uncover a key prosurvival modulator, Yip1A, which coordinates IRE1 signaling with PERK signaling to support the survival of HeLa and CaSki cervical cancer cells.
      Title: Novel prosurvival function of Yip1A in human cervical cancer cells: constitutive activation of the IRE1 and PERK pathways of the unfolded protein response.
    2. Yos1p associates with Yip1p and Yif1p, indicating Yos1p is a novel subunit of the Yip1p-Yif1p complex
      Title: Yos1p is a novel subunit of the Yip1p-Yif1p complex and is required for transport between the endoplasmic reticulum and the Golgi complex.
    3. Rab requirement is confined to a subset of Rab proteins that are localized to the Golgi apparatus.
      Title: Genetic analysis of yeast Yip1p function reveals a requirement for Golgi-localized rab proteins and rab-Guanine nucleotide dissociation inhibitor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle fusion with Golgi apparatus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in COPII-coated ER to Golgi transport vesicle IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transporter YIP1
    NP_011688.3
    • Integral membrane protein; required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; human homolog YIPF5 can complement yeast yip1 mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      842845..843591 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181301.3 → NP_011688.3  TPA: transporter YIP1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011688.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUV6, P53039
      UniProtKB/TrEMBL
      A0A8H4C0T0, C7GQ79, N1P9X6
      Conserved Domains (1) summary
      COG5080
      Location:3 → 248
      YIP1; Rab GTPase interacting factor, Golgi membrane protein [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53039.1

    Gene LinkOut

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