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    och1 Golgi alpha-1,6-mannosyltransferase Och1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543147, updated on 18-Sep-2024

    Summary

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    Official Symbol
    och1
    Official Full Name
    Golgi alpha-1,6-mannosyltransferase Och1
    Primary source
    PomBase:SPAC1006.05c
    Locus tag
    SPOM_SPAC1006.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See och1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (5078289..5080521, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene protein mcp3 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene RhoGEF for Rho1 Rgf2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The och1 mutant of Schizosaccharomyces pombe produces galactosylated core structures of N-linked oligosaccharides. Ohashi T, et al. Biosci Biotechnol Biochem, 2009 Feb. PMID 19202278
    2. Schizosaccharomyces pombe och1(+) encodes alpha-1,6-mannosyltransferase that is involved in outer chain elongation of N-linked oligosaccharides. Yoko-o T, et al. FEBS Lett, 2001 Jan 26. PMID 11231017
    3. The fission yeast gmn2(+) gene encodes an ERD1 homologue of Saccharomyces cerevisiae required for protein glycosylation and retention of luminal endoplasmic reticulum proteins. Tanaka N, et al. J Gen Appl Microbiol, 2021 Jun 3. PMID 33536395
    4. Production of heterologous glycoproteins by a glycosylation-defective alg3och1 mutant of Schizosaccharomyces pombe. Ohashi T, et al. J Biotechnol, 2010 Nov. PMID 20854854
    5. N- and O-linked oligosaccharides completely lack galactose residues in the gms1och1 mutant of Schizosaccharomyces pombe. Ohashi T, et al. Appl Microbiol Biotechnol, 2010 Mar. PMID 19844703

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In this study, we deleted the alg3(+) gene in the och1Delta mutant and analyzed the detailed oligosaccharide structures in alg3Deltaoch1Delta double mutant of Schizosaccharomyces pombe.
      Title: Production of heterologous glycoproteins by a glycosylation-defective alg3och1 mutant of Schizosaccharomyces pombe.
    2. The N-linked oligosaccharides of gms1Deltaoch1Delta cells consisted of alpha1,2-linked Man-extended core oligosaccharides (Man(8-12)GlcNAc2) from which the fission yeast-specific alpha-linked Gal residues were completely absent.
      Title: N- and O-linked oligosaccharides completely lack galactose residues in the gms1och1 mutant of Schizosaccharomyces pombe.
    3. structure of the N-linked oligosaccharides of och1Delta cells
      Title: The och1 mutant of Schizosaccharomyces pombe produces galactosylated core structures of N-linked oligosaccharides.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables alpha-1,6-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,6-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables alpha-1,6-mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables glycolipid 1,6-alpha-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannosyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall mannoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation via asparagine IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mannan polymerase II complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mannan polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Golgi alpha-1,6-mannosyltransferase Och1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      5078289..5080521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020281.3 → NP_594852.1  Golgi alpha-1,6-mannosyltransferase Och1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594852.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9UTR6
      Conserved Domains (2) summary
      COG3774
      Location:101 → 396
      OCH1; Mannosyltransferase OCH1 or related enzyme [Cell wall/membrane/envelope biogenesis]
      pfam04488
      Location:155 → 246
      Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
    Nucleotide Protein
    Heading Accession and Version

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