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    RPP2A ribosomal protein P2A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854118, updated on 17-May-2024

    Summary

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    Gene symbol
    RPP2A
    Gene description
    ribosomal protein P2A
    Primary source
    FungiDB:YOL039W
    Locus tag
    YOL039W
    See related
    SGD:S000005399; AllianceGenome:SGD:S000005399; VEuPathDB:YOL039W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RPL44; RPLA2
    Summary
    A structural constituent of ribosome. Involved in cytoplasmic translation. Part of cytosolic large ribosomal subunit. Orthologous to human RPLP2 (ribosomal protein lateral stalk subunit P2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPP2A in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (254297..254617)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Nop12p Neighboring gene ribosomal 40S subunit protein S15 Neighboring gene uncharacterized protein Neighboring gene proteasome core particle subunit alpha 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption of single-copy genes encoding acidic ribosomal proteins in Saccharomyces cerevisiae. Remacha M, et al. Mol Cell Biol, 1990 May. PMID 2183022, Free PMC Article
    2. Temporal genetic association and temporal genetic causality methods for dissecting complex networks. Lin L, et al. Nat Commun, 2018 Sep 28. PMID 30266904, Free PMC Article
    3. Independent genes coding for three acidic proteins of the large ribosomal subunit from Saccharomyces cerevisiae. Remacha M, et al. J Biol Chem, 1988 Jul 5. PMID 2837476
    4. Characterization of the yeast acidic ribosomal phosphoproteins using monoclonal antibodies. Proteins L44/L45 and L44' have different functional roles. Vilella MD, et al. Eur J Biochem, 1991 Mar 14. PMID 1706664
    5. Defects in the NC2 repressor affect both canonical and non-coding RNA polymerase II transcription initiation in yeast. Gómez-Navarro N, et al. BMC Genomics, 2016 Mar 3. PMID 26939779, Free PMC Article

    See all (111) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. P1/P2 heterodimers bind to P0 when both ribosomal subunits are joined and committed to translation, and they detached from the stalk, just after the small and large ribosomal subunits were separated from the mRNA.
      Title: The P1/P2 protein heterodimers assemble to the ribosomal stalk at the moment when the ribosome is committed to translation but not to the native 60S ribosomal subunit in Saccharomyces cerevisiae.
    2. The reported results support that while most ribosomes contain a P1alpha/P2beta-P0-P1beta/P2alpha structure in normal conditions, the stalk assembly mechanism can generate alternative compositions, which have been previously detected in the cell.
      Title: P1 and P2 protein heterodimer binding to the P0 protein of Saccharomyces cerevisiae is relatively non-specific and a source of ribosomal heterogeneity.
    3. The authors have found that neither P1 nor P2 directly interact with P0 unless the endogenous heterodimer partner is being expressed in the cell.
      Title: In vivo formation of a stable pentameric (P2alpha/P1beta)-P0-(P1alpha/P2beta) ribosomal stalk complex in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein kinase activator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables structural constituent of ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasmic translation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cytoplasmic translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cytoplasmic translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytosolic large ribosomal subunit IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytosolic large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribosomal protein P2A
    NP_014603.1
    • Ribosomal protein P2 alpha; a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; free (non-ribosomal) P2 stimulates the phosphorylation of the eIF2 alpha subunit (Sui2p) by Gcn2p; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      254297..254617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183293.1 → NP_014603.1  TPA: ribosomal protein P2A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014603.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W227, P05319
      UniProtKB/TrEMBL
      A0A6A5Q416, A6ZNH0, B3LJ19, C7GK08, C8ZHS5, G2WMJ4, N1NVP6
      Conserved Domains (1) summary
      cd05833
      Location:15 → 106
      Ribosomal_P2; Ribosomal protein P2. This subfamily represents the eukaryotic large ribosomal protein P2. Eukaryotic P1 and P2 are functionally equivalent to the bacterial protein L7/L12, but are not homologous to L7/L12. P2 is located in the L12 stalk, with proteins ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05319.1

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