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    dna2 DNA replication endonuclease-helicase Dna2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540148, updated on 22-Jun-2024

    Summary

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    Gene symbol
    dna2
    Gene description
    DNA replication endonuclease-helicase Dna2
    Locus tag
    SPOM_SPBC16D10.04C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPBC16D10.04c
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    Genomic context

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    See dna2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003423.3 (3592291..3596956, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA (guanine-N2-)-methyltransferase catalytic subunit Trm11 Neighboring gene ncRNA Neighboring gene EKC/KEOPS complex N(6)-L-threonylcarbamoyladenine synthase subunit Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cell wall alpha-1,3-glucan synthase Mok13

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Chromatin Response to Double-Strand DNA Breaks and Their Repair. Aleksandrov R, et al. Cells, 2020 Aug 7. PMID 32784607, Free PMC Article
    2. The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing. Hu J, et al. Cell, 2012 Jun 8. PMID 22682245
    3. Fission yeast Dna2 is required for generation of the telomeric single-strand overhang. Tomita K, et al. Mol Cell Biol, 2004 Nov. PMID 15485922, Free PMC Article
    4. Fission yeast cdc24(+) encodes a novel replication factor required for chromosome integrity. Gould KL, et al. Genetics, 1998 Jul. PMID 9649516, Free PMC Article
    5. Cdc24 Is Essential for Long-range End Resection in the Repair of Double-stranded DNA Breaks. Zhang H, et al. J Biol Chem, 2016 Nov 25. PMID 27729451, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Schizosaccharomyces pombe Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2.
      Title: Fission yeast Pxd1 promotes proper DNA repair by activating Rad16XPF and inhibiting Dna2.
    2. Dna2 cleavage of regressed nascent strands prevents fork reversal and thus stabilizes stalled forks to maintain genome stability during replication stress.
      Title: The intra-S phase checkpoint targets Dna2 to prevent stalled replication forks from reversing.
    3. Dna2 is involved in the generation of G-rich overhangs in both wild-type cells and taz1-d cells
      Title: Fission yeast Dna2 is required for generation of the telomeric single-strand overhang.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5' overhang single-stranded DNA endodeoxyribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Okazaki fragment processing involved in mitotic DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in double-strand break repair via homologous recombination TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in removal of RNA primer involved in mitotic DNA replication IC
    Inferred by Curator
    more info
    		  
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in replication fork reversal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork reversal IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to intra-S DNA damage checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome, telomeric repeat region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in nuclear replication fork IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 
    is_active_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA replication endonuclease-helicase Dna2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      3592291..3596956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022420.3 → NP_596499.2  DNA replication endonuclease-helicase Dna2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596499.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74241, Q9URU2, Q9UTT6, Q9UUK8
      Conserved Domains (5) summary
      COG1112
      Location:444 → 1352
      DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
      pfam08696
      Location:385 → 579
      Dna2; DNA replication factor Dna2
      pfam13087
      Location:1118 → 1316
      AAA_12; AAA domain
      cl00641
      Location:558 → 689
      Cas4_I-A_I-B_I-C_I-D_II-B; CRISPR/Cas system-associated protein Cas4
      cl21455
      Location:932 → 1096
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version

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