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    IZH3 Izh3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850710, updated on 1-Aug-2024

    Summary

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    Gene symbol
    IZH3
    Gene description
    Izh3p
    Primary source
    FungiDB:YLR023C
    Locus tag
    YLR023C
    See related
    SGD:S000004013; AllianceGenome:SGD:S000004013; VEuPathDB:YLR023C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable signaling receptor activity. Involved in cellular zinc ion homeostasis. Located in endoplasmic reticulum. Orthologous to human PAQR3 (progestin and adipoQ receptor family member 3). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See IZH3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (185498..187129, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Irc25p Neighboring gene guanine nucleotide exchange factor SDO1 Neighboring gene putative ubiquitin-protein ligase UBR2 Neighboring gene ESCRT-III subunit protein SNF7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The polyene antifungals, amphotericin B and nystatin, cause cell death in Saccharomyces cerevisiae by a distinct mechanism to amphibian-derived antimicrobial peptides. Serhan G, et al. Ann Clin Microbiol Antimicrob, 2014 May 12. PMID 24884795, Free PMC Article
    2. Phylogenetic and preliminary phenotypic analysis of yeast PAQR receptors: potential antifungal targets. Villa NY, et al. J Mol Evol, 2011 Oct. PMID 22009226, Free PMC Article
    3. Metalloregulation of yeast membrane steroid receptor homologs. Lyons TJ, et al. Proc Natl Acad Sci U S A, 2004 Apr 13. PMID 15060275, Free PMC Article
    4. An amphibian-derived, cationic, alpha-helical antimicrobial peptide kills yeast by caspase-independent but AIF-dependent programmed cell death. Morton CO, et al. Mol Microbiol, 2007 Jul. PMID 17587229
    5. The antifungal occidiofungin triggers an apoptotic mechanism of cell death in yeast. Emrick D, et al. J Nat Prod, 2013 May 24. PMID 23672235

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IZH2 and IZH3 gene dosage affects resistance to polyene antifungal drugs
      Title: Phylogenetic and preliminary phenotypic analysis of yeast PAQR receptors: potential antifungal targets.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular zinc ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular zinc ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Izh3p
    NP_013123.1
    • Membrane protein involved in zinc ion homeostasis; member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      185498..187129 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181910.1 → NP_013123.1  TPA: Izh3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013123.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY25, Q07959
      UniProtKB/TrEMBL
      A7A0S8, B3LSZ6, C7GXG9
      Conserved Domains (1) summary
      pfam03006
      Location:252 → 529
      HlyIII; Haemolysin-III related
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07959.1

    Gene LinkOut

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