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    CTF3 Ctf3p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851097, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CTF3
    Official Full Name
    Ctf3p
    Primary source
    SGD:S000004373
    Locus tag
    YLR381W
    See related
    AllianceGenome:SGD:S000004373; FungiDB:YLR381W; VEuPathDB:YLR381W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CHL3
    Summary
    Involved in several processes, including DNA replication initiation; establishment of mitotic sister chromatid cohesion; and mitotic spindle assembly checkpoint signaling. Located in kinetochore. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CTF3 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (879723..881924)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Csr1p Neighboring gene leucine--tRNA ligase NAM2 Neighboring gene DNA repair protein SMC6

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Role of Ctf3 and COMA subcomplexes in meiosis: Implication in maintaining Cse4 at the centromere and numeric spindle poles. Agarwal M, et al. Biochim Biophys Acta, 2015 Mar. PMID 25562757
    2. Genetic control of chromosome stability in the yeast Saccharomyces cerevisiae. Kouprina NYu, et al. Yeast, 1988 Dec. PMID 3064490
    3. The structure of the yeast Ctf3 complex. Hinshaw SM, et al. Elife, 2019 Jun 13. PMID 31194673, Free PMC Article
    4. Identification and genetic mapping of CHL genes controlling mitotic chromosome transmission in yeast. Kouprina N, et al. Yeast, 1993 Jan. PMID 8442383
    5. Crystal structure of the Cenp-HIKHead-TW sub-module of the inner kinetochore CCAN complex. Zhang Z, et al. Nucleic Acids Res, 2020 Nov 4. PMID 32976599, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore.
      Title: Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment of mitotic sister chromatid cohesion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ctf3p
    NP_013485.1
    • Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules; required for the spindle assembly checkpoint; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-I and fission yeast mis6

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      879723..881924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182270.1 → NP_013485.1  TPA: Ctf3p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013485.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZ16, Q12748, Q7LHY6
      UniProtKB/TrEMBL
      A7A1Q6, G2WJJ6, N1P7A4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12748.1

    Gene LinkOut

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