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    gcs2 glutamate-cysteine ligase regulatory subunit Gcs2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539059, updated on 18-Sep-2024

    Summary

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    Official Symbol
    gcs2
    Official Full Name
    glutamate-cysteine ligase regulatory subunit Gcs2
    Primary source
    PomBase:SPCC737.06c
    Locus tag
    SPOM_SPCC737.06C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See gcs2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003421.2 (1895954..1897546, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene peroxin Pex28/29 Neighboring gene DNA polymerase alpha-associated DNA helicase A Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene midasin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dual recruitment of Cdc48 (p97)-Ufd1-Npl4 ubiquitin-selective segregase by small ubiquitin-like modifier protein (SUMO) and ubiquitin in SUMO-targeted ubiquitin ligase-mediated genome stability functions. Nie M, et al. J Biol Chem, 2012 Aug 24. PMID 22730331, Free PMC Article
    2. Proximity-dependent biotinylation mediated by TurboID to identify protein-protein interaction networks in yeast. Larochelle M, et al. J Cell Sci, 2019 May 31. PMID 31064814
    3. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article
    4. A central role for TOR signalling in a yeast model for juvenile CLN3 disease. Bond ME, et al. Microb Cell, 2015 Nov 11. PMID 28357272, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables glutamate-cysteine ligase catalytic subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate-cysteine ligase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutamate-cysteine ligase regulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular detoxification NAS
    Non-traceable Author Statement
    more info
    		  
    involved_in cysteine metabolic process IC
    Inferred by Curator
    more info
    		  
    involved_in glutathione biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    part_of glutamate-cysteine ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutamate-cysteine ligase regulatory subunit Gcs2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1895954..1897546 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023359.3 → NP_588368.1  glutamate-cysteine ligase regulatory subunit Gcs2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588368.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94246
      Conserved Domains (1) summary
      COG0656
      Location:4 → 283
      ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    Nucleotide Protein
    Heading Accession and Version

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