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    hst2 histone deacetylase, Sirtuin family, NAD-dependent Hst2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538868, updated on 14-Nov-2024

    Summary

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    Official Symbol
    hst2
    Official Full Name
    histone deacetylase, Sirtuin family, NAD-dependent Hst2
    Primary source
    PomBase:SPCC132.02
    Locus tag
    SPOM_SPCC132.02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See hst2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003421.2 (1328952..1330790)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene prohibitin Phb2 Neighboring gene ncRNA Neighboring gene ribosome quality control complex subunit Rqc2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Global analysis of gel mobility of proteins and its use in target identification. Shirai A, et al. J Biol Chem, 2008 Apr 18. PMID 18292091
    2. Specific functions for the fission yeast Sirtuins Hst2 and Hst4 in gene regulation and retrotransposon silencing. Durand-Dubief M, et al. EMBO J, 2007 May 16. PMID 17446861, Free PMC Article
    3. Impaired coenzyme A synthesis in fission yeast causes defective mitosis, quiescence-exit failure, histone hypoacetylation and fragile DNA. Nakamura T, et al. Open Biol, 2012 Sep. PMID 23091701, Free PMC Article
    4. Large scale screening of genetic interaction with sgf73(+) in fission yeast. Guo Y, et al. Yi Chuan, 2014 Jul. PMID 25076038
    5. Significant conservation of synthetic lethal genetic interaction networks between distantly related eukaryotes. Dixon SJ, et al. Proc Natl Acad Sci U S A, 2008 Oct 28. PMID 18931302, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone H3K14 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K18 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K4 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K56 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3K9 deacetylase activity, NAD-dependent EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables histone H4K16 deacetylase activity, NAD-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone deacetylase activity, NAD-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein lysine deacetylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in pericentric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rDNA heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rDNA heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromosome, subtelomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in mating-type region heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in pericentric heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in rDNA heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone deacetylase, Sirtuin family, NAD-dependent Hst2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1328952..1330790
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023136.3 → NP_588147.1  histone deacetylase, Sirtuin family, NAD-dependent Hst2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588147.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9USN7
      Conserved Domains (1) summary
      cd01408
      Location:28 → 262
      SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
    Nucleotide Protein
    Heading Accession and Version

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