ISD11 Isd11p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ISD11
Gene description: Isd11p
Primary source: FungiDB:YER048W-A
Locus tag: YER048W-A
See related: SGD:S000007237; AllianceGenome:SGD:S000007237; VEuPathDB:YER048W-A
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to cysteine desulfurase activity. Involved in iron-sulfur cluster assembly. Located in mitochondrial matrix. Is extrinsic component of mitochondrial inner membrane. Part of L-cysteine desulfurase complex. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 19. Orthologous to human LYRM4 (LYR motif containing 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ISD11 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (250718..251002)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results show that Nfs1 adopts a higher oligomeric state in the Isd11-bound form compared to that in the free form
Title: The effect of the adaptor protein Isd11 on the quaternary structure of the eukaryotic cysteine desulphurase Nfs1.
Whereas Nfs1p by itself was inactive, the Nfs1p.Isd11p complex formed persulfide and was active as a cysteine desulfurase. In the absence of Isd11p, Nfs1p was able to bind the substrate cysteine but failed to form a persulfide.
Title: Persulfide formation on mitochondrial cysteine desulfurase: enzyme activation by a eukaryote-specific interacting protein and Fe-S cluster synthesis.
Isd11 acts together with Nfs1 in an early step in the biogenesis of Fe/S proteins.
Title: The Nfs1 interacting protein Isd11 has an essential role in Fe/S cluster biogenesis in mitochondria.
Isd11 is an indispensable eukaryotic component of the mitochondrial machinery for biogenesis of Fe/S proteins.
Title: Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to cysteine desulfurase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in iron-sulfur cluster assembly	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of L-cysteine desulfurase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of L-cysteine desulfurase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Isd11p

NP_010968.1

Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis; exclusive to eukaryotes, implicated as eukaryotic supplement to the bacterium-derived Fe-S cluster (ISC) assembly apparatus; involved in regulation of iron metabolism; member of the LYR protein family

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

250718..251002

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001184330.1 → NP_010968.1 TPA: Isd11p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010968.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLV0, Q6Q560

UniProtKB/TrEMBL

A0A6A5PYD1, A6ZQZ9, B3LS62, C7GSJ7, C8Z752, G2WCT3, N1P3D0

Conserved Domains (1) summary

cd20264
Location:11 → 79

Complex1_LYR_LYRM4; LYR (leucine-tyrosine-arginine) motif found in LYR motif-containing protein 4 (LYRM4) and similar proteins