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    nsk1 Clp1-interacting, microtubule plus-end binding Nsk1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 3361470, updated on 22-Jun-2024

    Summary

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    Gene symbol
    nsk1
    Gene description
    Clp1-interacting, microtubule plus-end binding Nsk1
    Locus tag
    SPOM_SPAC3G9.01
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Old locus tag
    SPAC3G9.01
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    Genomic context

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    See nsk1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (3181430..3183327, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L23 Neighboring gene ncRNA Neighboring gene 3-oxoacyl-[acyl-carrier-protein] reductase Oar2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cdk1 phosphorylation of the kinetochore protein Nsk1 prevents error-prone chromosome segregation. Chen JS, et al. J Cell Biol, 2011 Nov 14. PMID 22065639, Free PMC Article
    2. Mitotic substrates of the kinase aurora with roles in chromatin regulation identified through quantitative phosphoproteomics of fission yeast. Koch A, et al. Sci Signal, 2011 Jun 28. PMID 21712547
    3. Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B. Buttrick GJ, et al. Mol Biol Cell, 2011 Dec. PMID 21965289, Free PMC Article
    4. Comprehensive proteomics analysis reveals new substrates and regulators of the fission yeast clp1/cdc14 phosphatase. Chen JS, et al. Mol Cell Proteomics, 2013 May. PMID 23297348, Free PMC Article
    5. The fission yeast nucleoporin Alm1 is required for proteasomal degradation of kinetochore components. Salas-Pino S, et al. J Cell Biol, 2017 Nov 6. PMID 28974540, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nsk1 ensures accurate chromosome segregation by promoting the tethering of kinetochores to spindle poles during anaphase B.
      Title: Nsk1 ensures accurate chromosome segregation by promoting association of kinetochores to spindle poles during anaphase B.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables microtubule plus-end binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in centromere clustering at the mitotic interphase nuclear envelope IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Nsk1-Dlc1 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in inner plaque of mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle HDA PubMed 
    is_active_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitotic spindle pole body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus HDA PubMed 
    is_active_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of outer kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Clp1-interacting, microtubule plus-end binding Nsk1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      3181430..3183327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001019512.3 → NP_001018258.1  Clp1-interacting, microtubule plus-end binding Nsk1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_001018258.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q7LL22
      Conserved Domains (1) summary
      PTZ00449
      Location:103 → 354
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    T11637.1

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