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    REX2 Rex2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850748, updated on 29-Jun-2024

    Summary

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    Gene symbol
    REX2
    Gene description
    Rex2p
    Primary source
    FungiDB:YLR059C
    Locus tag
    YLR059C
    See related
    SGD:S000004049; AllianceGenome:SGD:S000004049; VEuPathDB:YLR059C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YNT20
    Summary
    Enables 3'-5'-exoribonuclease activity. Involved in mitochondrial genome maintenance and ncRNA 3'-end processing. Located in mitochondrion. Orthologous to human REXO2 (RNA exonuclease 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See REX2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (259738..260547, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene putative mannosidase MNL2 Neighboring gene glycine hydroxymethyltransferase SHM2 Neighboring gene phenylalanine--tRNA ligase subunit beta Neighboring gene ribosomal 60S subunit protein L22A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of TRZ1, a yeast homolog of the human candidate prostate cancer susceptibility gene ELAC2 encoding tRNase Z. Chen Y, et al. BMC Mol Biol, 2005 May 13. PMID 15892892, Free PMC Article
    2. YNT20, a bypass suppressor of yme1 yme2, encodes a putative 3'-5' exonuclease localized in mitochondria of Saccharomyces cerevisiae. Hanekamp T, et al. Curr Genet, 1999 Jan. PMID 9933355
    3. The Rtr1p CTD phosphatase autoregulates its mRNA through a degradation pathway involving the REX exonucleases. Hodko D, et al. RNA, 2016 Apr. PMID 26843527, Free PMC Article
    4. Pan2-Pan3 complex, together with Ccr4-Not complex, has a role in the cell growth on non-fermentable carbon sources. Fujii S, et al. Biochem Biophys Res Commun, 2021 Sep 17. PMID 34280615
    5. Three conserved members of the RNase D family have unique and overlapping functions in the processing of 5S, 5.8S, U4, U5, RNase MRP and RNase P RNAs in yeast. van Hoof A, et al. EMBO J, 2000 Mar 15. PMID 10716935, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3'-5' exonuclease activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables 3'-5'-RNA exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5'-RNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3'-5'-RNA exonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in U4 snRNA 3'-end processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in U4 snRNA 3'-end processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in U5 snRNA 3'-end processing IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rex2p
    NP_013160.1
    • 3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease; role in preventing L-A mycovirus pathogenesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      259738..260547 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181946.1 → NP_013160.1  TPA: Rex2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013160.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY61, E9P909, P54964
      UniProtKB/TrEMBL
      A0A8H4BWZ2, N1P6D6
      Conserved Domains (1) summary
      COG1949
      Location:48 → 240
      Orn; Oligoribonuclease (3'-5' exoribonuclease) [RNA processing and modification]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54964.1

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