DPH1 2-(3-amino-3-carboxypropyl)histidine synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: DPH1
Gene description: 2-(3-amino-3-carboxypropyl)histidine synthase
Primary source: FungiDB:YIL103W
Locus tag: YIL103W
See related: SGD:S000001365; AllianceGenome:SGD:S000001365
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable transferase activity. Involved in peptidyl-diphthamide biosynthetic process from peptidyl-histidine. Located in cytoplasm. Orthologous to human DPH1 (diphthamide biosynthesis 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See DPH1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (171751..173028)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 2-(3-amino-3-carboxypropyl)histidine synthase activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein histidyl modification to diphthamide	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein histidyl modification to diphthamide	IEA Inferred from Electronic Annotation more info
involved_in protein histidyl modification to diphthamide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: 2-(3-amino-3-carboxypropyl)histidine synthase

NP_012163.1

EC 2.5.1.108

Protein required for synthesis of diphthamide; required along with Dph2p, Kti11p, Jjj3p, and Dph5p; diphthamide is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); forms a complex with Dph2p that catalyzes the first step of diphthamide biosynthesis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

171751..173028

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179451.1 → NP_012163.1 TPA: 2-(3-amino-3-carboxypropyl)histidine synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012163.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVI4, P40487

UniProtKB/TrEMBL

A0A8H4FCF9, B3LTV0, B5VKK7, C7GKM9, C8ZAE3, N1P4F2

Conserved Domains (1) summary

COG1736
Location:69 → 421

DPH2; Diphthamide synthase subunit DPH2 [Translation, ribosomal structure and biogenesis]