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    AVT7 Avt7p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854721, updated on 17-May-2024

    Summary

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    Gene symbol
    AVT7
    Gene description
    Avt7p
    Primary source
    FungiDB:YIL088C
    Locus tag
    YIL088C
    See related
    SGD:S000001350; AllianceGenome:SGD:S000001350; VEuPathDB:YIL088C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable L-amino acid transmembrane transporter activity. Involved in amino acid transport and regulation of sporulation. Located in fungal-type vacuole; plasma membrane; and vacuolar membrane. Orthologous to several human genes including SLC38A7 (solute carrier family 38 member 7) and SLC38A8 (solute carrier family 38 member 8). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See AVT7 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (197931..199403, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Glu Neighboring gene Aim19p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A vacuolar membrane protein Avt7p is involved in transport of amino acid and spore formation in Saccharomyces cerevisiae. Tone J, et al. Biosci Biotechnol Biochem, 2015. PMID 25266154
    2. The vacuolar amino acid transport system is a novel, direct target of GATA transcription factors. Sato A, et al. Biosci Biotechnol Biochem, 2021 Feb 24. PMID 33624780
    3. Vacuolar amino acid transporters upregulated by exogenous proline and involved in cellular localization of proline in Saccharomyces cerevisiae. Nishida I, et al. J Gen Appl Microbiol, 2016 Jul 14. PMID 27246536
    4. A family of yeast proteins mediating bidirectional vacuolar amino acid transport. Russnak R, et al. J Biol Chem, 2001 Jun 29. PMID 11274162
    5. An overexpression screen in Saccharomyces cerevisiae identifies novel genes that affect endocytic protein trafficking. Arlt H, et al. Traffic, 2011 Nov. PMID 21777356

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. physiological importance of Avt7p-dependent efflux of amino acid from vacuoles under nutrient-poor condition
      Title: A vacuolar membrane protein Avt7p is involved in transport of amino acid and spore formation in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables L-arginine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-glutamate transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-histidine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-lysine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-serine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-tyrosine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amino acid transmembrane transporter activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-arginine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-glutamate transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-histidine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-lysine transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in L-serine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amino acid transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of sporulation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tyrosine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Avt7p
    NP_012178.1
    • Vacuolar amino acid transporter; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      197931..199403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179436.1 → NP_012178.1  TPA: Avt7p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012178.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVJ9, P40501
      UniProtKB/TrEMBL
      A0A8H4FCG3, C7GKL5
      Conserved Domains (1) summary
      pfam01490
      Location:4 → 477
      Aa_trans; Transmembrane amino acid transporter protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40501.1

    Gene LinkOut

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