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    ctr4 Cu(2+) transporter complex subunit Ctr4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538731, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ctr4
    Official Full Name
    Cu(2+) transporter complex subunit Ctr4
    Primary source
    PomBase:SPCC1393.10
    Locus tag
    SPOM_SPCC1393.10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See ctr4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (818459..819361)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene telomere cap complex subunit Ten1 Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional dissection of Ctr4 and Ctr5 amino-terminal regions reveals motifs with redundant roles in copper transport. Beaudoin J, et al. Microbiology (Reading), 2006 Jan. PMID 16385131
    2. Copper-dependent trafficking of the Ctr4-Ctr5 copper transporting complex. Ioannoni R, et al. PLoS One, 2010 Aug 4. PMID 20694150, Free PMC Article
    3. Cell-surface copper transporters and superoxide dismutase 1 are essential for outgrowth during fungal spore germination. Plante S, et al. J Biol Chem, 2017 Jul 14. PMID 28572514, Free PMC Article
    4. Identification of a novel high affinity copper transport complex in the fission yeast Schizosaccharomyces pombe. Zhou H, et al. J Biol Chem, 2001 Jun 8. PMID 11274192
    5. Ctr6, a vacuolar membrane copper transporter in Schizosaccharomyces pombe. Bellemare DR, et al. J Biol Chem, 2002 Nov 29. PMID 12244050

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors propose that the Ctr4 central domain mediates Cu transport in this hetero-complex, whereas the Ctr5 carboxyl-terminal domains functions in the regulation of trafficking of the Cu transport complex to the cell surface. [Ctr4 & Ctr5]
      Title: Dissection of the relative contribution of the Schizosaccharomyces pombe Ctr4 and Ctr5 proteins to the copper transport and cell surface delivery functions.
    2. Ctr4 and Ctr5 proteins co-localize at the plasma membrane shortly after meiotic induction, whereas Ctr6 is located on the membrane of vacuoles.
      Title: Characterization of Schizosaccharomyces pombe copper transporter proteins in meiotic and sporulating cells.
    3. a copper-dependent internalization and recycling of the heteromeric Ctr4-Ctr5 complex
      Title: Copper-dependent trafficking of the Ctr4-Ctr5 copper transporting complex.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables copper ion transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in copper ion import across plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in copper ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cu(2+) transporter complex subunit Ctr4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      818459..819361
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022959.3 → NP_587968.1  Cu(2+) transporter complex subunit Ctr4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587968.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94722
      Conserved Domains (1) summary
      pfam04145
      Location:121 → 248
      Ctr; Ctr copper transporter family
    Nucleotide Protein
    Heading Accession and Version

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