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    CUE2 Cue2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853772, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CUE2
    Official Full Name
    Cue2p
    Primary source
    SGD:S000001573
    Locus tag
    YKL090W
    See related
    AllianceGenome:SGD:S000001573; FungiDB:YKL090W; VEuPathDB:YKL090W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA endonuclease activity and ubiquitin binding activity. Involved in nuclear-transcribed mRNA catabolic process, no-go decay. Is active in cytosolic ribosome. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CUE2 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (271878..273209)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene GTPase-activating protein BUD2 Neighboring gene phosphatidylinositol/phosphatidylcholine-binding protein Neighboring gene Mif2p Neighboring gene phosphopantothenoylcysteine decarboxylase complex subunit CAB3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay. Tomomatsu S, et al. Nucleic Acids Res, 2023 Jan 11. PMID 36583309, Free PMC Article
    2. Most, but not all, yeast strains in the deletion library contain the [PIN(+)] prion. Manogaran AL, et al. Yeast, 2010 Mar. PMID 20014044, Free PMC Article
    3. NONU-1 Encodes a Conserved Endonuclease Required for mRNA Translation Surveillance. Glover ML, et al. Cell Rep, 2020 Mar 31. PMID 32234470, Free PMC Article
    4. Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding. Kang RS, et al. Cell, 2003 May 30. PMID 12787503
    5. The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay. D'Orazio KN, et al. Elife, 2019 Jun 20. PMID 31219035, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay.
      Title: Two modes of Cue2-mediated mRNA cleavage with distinct substrate recognition initiate no-go decay.
    2. we show that the Cue2-dependent pathway becomes a major contributor to NGD in cells depleted of factors required for the resolution of stalled ribosome complexes.
      Title: The endonuclease Cue2 cleaves mRNAs at stalled ribosomes during No Go Decay.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables K63-linked polyubiquitin modification-dependent protein binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear-transcribed mRNA catabolic process, no-go decay IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Cue2p
    NP_012833.1
    • Ubiquitin-binding endonuclease involved in mRNA decay; recruited to stalled ribosomes to promote breakdown of transcript body of nuclear-transcribed mRNA with stalls in translation elongation; cleaves mRNA within A site of colliding ribosome; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      271878..273209
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179656.1 → NP_012833.1  TPA: Cue2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012833.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXJ8, P36075
      UniProtKB/TrEMBL
      A6ZZM7, B5VM67, G2WHU3, N1P291
      Conserved Domains (3) summary
      smart00463
      Location:344 → 440
      SMR; Small MutS-related domain
      cd14374
      Location:10 → 51
      CUE1_Cue2p_like; CUE1 domain found in yeast ubiquitin-binding protein CUE2 (Cue2p) and similar proteins
      cd14375
      Location:57 → 94
      CUE2_Cue2p_like; CUE2 domain found in yeast ubiquitin-binding protein CUE2 (Cue2p) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36075.1

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