U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    MSH5 MutS family protein MSH5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851401, updated on 17-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    MSH5
    Gene description
    MutS family protein MSH5
    Primary source
    FungiDB:YDL154W
    Locus tag
    YDL154W
    See related
    SGD:S000002313; AllianceGenome:SGD:S000002313
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to DNA binding activity. Involved in reciprocal meiotic recombination. Located in nuclear chromosome. Part of MutSgamma complex. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and primary ovarian insufficiency 13. Orthologous to human MSH5 (mutS homolog 5). [provided by Alliance of Genome Resources, Apr 2022]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See MSH5 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (178334..181039)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Cmr1p Neighboring gene B-type cyclin CLB3 Neighboring gene rRNA-processing protein SAS10 Neighboring gene DNA-directed RNA polymerase III subunit C53

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A single amino acid substitution in MSH5 results in DNA alkylation tolerance. Bawa S, et al. Gene, 2003 Oct 2. PMID 14557077
    2. A mutation in the MSH5 gene results in alkylation tolerance. Bawa S, et al. Cancer Res, 1997 Jul 1. PMID 9205082
    3. Regulation of Msh4-Msh5 association with meiotic chromosomes in budding yeast. Nandanan KG, et al. Genetics, 2021 Oct 2. PMID 34849874, Free PMC Article
    4. MutSγ-Induced DNA Conformational Changes Provide Insights into Its Role in Meiotic Recombination. Lahiri S, et al. Biophys J, 2018 Dec 4. PMID 30467025, Free PMC Article
    5. Structural insights into Saccharomyces cerevisiae Msh4-Msh5 complex function using homology modeling. Rakshambikai R, et al. PLoS One, 2013. PMID 24244354, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Heterozygosity alters Msh5 binding to meiotic chromosomes in the baker's yeast.
      Title: Heterozygosity alters Msh5 binding to meiotic chromosomes in the baker's yeast.
    2. Regulation of Msh4-Msh5 association with meiotic chromosomes in budding yeast.
      Title: Regulation of Msh4-Msh5 association with meiotic chromosomes in budding yeast.
    3. a structural rationale for the meiotic defects observed in the msh4/5 point mutations. The mutations are likely to affect stability of the Msh4/5 proteins and/or interactions with DNA.
      Title: Structural insights into Saccharomyces cerevisiae Msh4-Msh5 complex function using homology modeling.
    4. Msh4 and msh5 mutants displayed reduced crossing over in meiosis but maintained wild-type spore viability.
      Title: Genetic analysis of baker's yeast Msh4-Msh5 reveals a threshold crossover level for meiotic viability.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chiasma assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiosis I IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MutSgamma complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    MutS family protein MSH5
    NP_010127.1
    • Protein of the MutS family; forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      178334..181039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180214.1 → NP_010127.1  TPA: MutS family protein MSH5 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010127.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRJ6, Q12175
      UniProtKB/TrEMBL
      A0A8H8UME2, G2WC09
      Conserved Domains (1) summary
      COG0249
      Location:1 → 898
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12175.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous