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    GLG1 glycogenin glucosyltransferase GLG1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853932, updated on 17-May-2024

    Summary

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    Gene symbol
    GLG1
    Gene description
    glycogenin glucosyltransferase GLG1
    Primary source
    FungiDB:YKR058W
    Locus tag
    YKR058W
    See related
    SGD:S000001766; AllianceGenome:SGD:S000001766; VEuPathDB:YKR058W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glycogenin glucosyltransferase activity. Involved in glycogen biosynthetic process. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in glycogen storage disease and glycogen storage disease XV. Orthologous to several human genes including GYG1 (glycogenin 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See GLG1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (552770..554620)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene tRNA (uracil(54)-C(5))-methyltransferase Neighboring gene ribosomal 40S subunit protein S21A Neighboring gene translation initiation factor eIF4A Neighboring gene Utp30p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Initiation of glycogen synthesis in yeast. Requirement of multiple tyrosine residues for function of the self-glucosylating Glg proteins in vivo. Mu J, et al. J Biol Chem, 1996 Oct 25. PMID 8900126
    2. Dynamic responses of reserve carbohydrate metabolism under carbon and nitrogen limitations in Saccharomyces cerevisiae. Parrou JL, et al. Yeast, 1999 Feb. PMID 10077186
    3. Requirement of the self-glucosylating initiator proteins Glg1p and Glg2p for glycogen accumulation in Saccharomyces cerevisiae. Cheng C, et al. Mol Cell Biol, 1995 Dec. PMID 8524228, Free PMC Article
    4. Multi-gene phylogenetic analysis reveals that shochu-fermenting Saccharomyces cerevisiae strains form a distinct sub-clade of the Japanese sake cluster. Futagami T, et al. Yeast, 2017 Oct. PMID 28703391
    5. Role of reserve carbohydrates in the growth dynamics of Saccharomyces cerevisiae. Guillou V, et al. FEMS Yeast Res, 2004 Sep. PMID 15450184

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables UDP-alpha-D-glucose:glucosyl-glycogenin alpha-D-glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycogenin glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycogenin glucosyltransferase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycogen biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycogen biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glycogenin glucosyltransferase GLG1
    NP_012984.2
    • Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; SWAT-GFP and mCherry fusion proteins localize to the cell periphery and vacuole respectively; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      552770..554620
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179848.1 → NP_012984.2  TPA: glycogenin glucosyltransferase GLG1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012984.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXB9, P36143
      UniProtKB/TrEMBL
      A0A8H4BYE2, G2WI86, N1P2Q9
      Conserved Domains (2) summary
      cd02537
      Location:6 → 279
      GT8_Glycogenin; Glycogenin belongs the GT 8 family and initiates the biosynthesis of glycogen
      NF033845
      Location:295 → 587
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36143.4

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