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    DAK2 dihydroxyacetone kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850491, updated on 18-Sep-2024

    Summary

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    Official Symbol
    DAK2
    Official Full Name
    dihydroxyacetone kinase
    Primary source
    SGD:S000001841
    Locus tag
    YFL053W
    See related
    AllianceGenome:SGD:S000001841; FungiDB:YFL053W; VEuPathDB:YFL053W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables glycerone kinase activity. Involved in cellular response to toxic substance and glycerol to glycerone phosphate metabolic process. Predicted to be active in cytosol. Orthologous to human TKFC (triokinase and FMN cyclase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DAK2 in Genome Data Viewer
    Location:
    chromosome: VI
    Exon count:
    1
    Sequence:
    Chromosome: VI; NC_001138.5 (23423..25198)

    Chromosome VI - NC_001138.5Genomic Context describing neighboring genes Neighboring gene Agp3p Neighboring gene Aqy3p Neighboring gene DNA-binding domain containing protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001138.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dihydroxyacetone-induced death is accompanied by advanced glycation endproduct formation in selected proteins of Saccharomyces cerevisiae and Caenorhabditis elegans. Molin M, et al. Proteomics, 2007 Oct. PMID 17890650
    2. Dihydroxyacetone detoxification in Saccharomyces cerevisiae involves formaldehyde dissimilation. Molin M, et al. Mol Microbiol, 2006 May. PMID 16677304
    3. Fragmentation of dihydroxyacetone kinase 1 from Saccharomyces cerevisiae indicates a two-domain structure. Molin M, et al. Proteomics, 2003 May. PMID 12748953
    4. Cloning, sequencing and characterization of a gene encoding dihydroxyacetone kinase from Zygosaccharomyces rouxii NRRL2547. Wang ZX, et al. Yeast, 2002 Dec. PMID 12478592
    5. Dihydroxyacetone kinases in Saccharomyces cerevisiae are involved in detoxification of dihydroxyacetone. Molin M, et al. J Biol Chem, 2003 Jan 17. PMID 12401799

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerone kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glycerone kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerone kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glycerone kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, alcohol group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables triokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in anaerobic glycerol catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycerol metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycerol to glycerone phosphate metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dihydroxyacetone kinase
    NP_116602.1
    • Dihydroxyacetone kinase; required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001138.5 Reference assembly

      Range
      23423..25198
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179914.1 → NP_116602.1  TPA: dihydroxyacetone kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_116602.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTH7, P43550
      UniProtKB/TrEMBL
      C7GY59, N1P4R0
      Conserved Domains (1) summary
      TIGR02361
      Location:4 → 586
      dak_ATP; dihydroxyacetone kinase, ATP-dependent
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43550.1

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