CAF20 Caf20p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CAF20
Gene description: Caf20p
Primary source: FungiDB:YOR276W
Locus tag: YOR276W
See related: SGD:S000005802; AllianceGenome:SGD:S000005802
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CAF2; CAP20
Summary: Enables eukaryotic initiation factor 4E binding activity. Involved in negative regulation of translation; positive regulation of cytoplasmic mRNA processing body assembly; and positive regulation of translation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CAF20 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (841333..841818)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overlapping regions of Caf20 mediate its interactions with the mRNA-5'cap-binding protein eIF4E and with ribosomes.
Title: Overlapping regions of Caf20 mediate its interactions with the mRNA-5'cap-binding protein eIF4E and with ribosomes.
We propose that the eIF4E/p20/mRNA complex serves as a stable depository of mRNAs existing in a dynamic equilibrium with other complexes such as eIF4E/eIF4G (required for translation) and eIF4E/Eap1 (required for mRNA degradation)
Title: Properties of the ternary complex formed by yeast eIF4E, p20 and mRNA.
Crystal structures of the yeast eIF4E bound to p20 were determined.The canonical and non-canonical motifs in 4E-BPs and eIF4G contribute differently to the affinity for eIF4E.
Title: Structural motifs in eIF4G and 4E-BPs modulate their binding to eIF4E to regulate translation initiation in yeast.
We suggest that Caf20 plays a critical role in Ste12 protein expression and in the control of P-body formation.
Title: Roles of eIF4E-binding protein Caf20 in Ste12 translation and P-body formation in yeast.
This work has provided evidence that Caf20p regulates translation of long mRNAs encoding larger proteins via the classic eIF4E-binding motif.
Title: The 4E-BP Caf20p Mediates Both eIF4E-Dependent and Independent Repression of Translation.
Caf20 and Dhh1 control filamentation by regulating STE12 translation.
Title: Identification of translational regulation target genes during filamentous growth in Saccharomyces cerevisiae: regulatory role of Caf20 and Dhh1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables eukaryotic initiation factor 4E binding	IDA Inferred from Direct Assay more info	PubMed
enables eukaryotic initiation factor 4E binding	IEA Inferred from Electronic Annotation more info
enables translation initiation factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in filamentous growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytoplasmic mRNA processing body assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of translation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IEA Inferred from Electronic Annotation more info
involved_in translational initiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Caf20p

NP_014919.3

Phosphoprotein of the mRNA cap-binding complex; involved in translational control; repressor of cap-dependent translational initiation; translational activator of select mRNAs during filamentous growth; competes with eIF4G for binding to eIF4E