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    DCR2 phosphoprotein phosphatase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851075, updated on 29-Jun-2024

    Summary

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    Gene symbol
    DCR2
    Gene description
    phosphoprotein phosphatase
    Primary source
    FungiDB:YLR361C
    Locus tag
    YLR361C
    See related
    SGD:S000004353; AllianceGenome:SGD:S000004353; VEuPathDB:YLR361C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphoprotein phosphatase activity. Involved in negative regulation of endoplasmic reticulum unfolded protein response; protein dephosphorylation; and traversing start control point of mitotic cell cycle. Located in fungal-type vacuole. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DCR2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (847388..849124, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Rsc2p Neighboring gene uncharacterized protein Neighboring gene adenylosuccinase ADE13 Neighboring gene Vps38p Neighboring gene uncharacterized protein Neighboring gene mitogen-activated protein kinase kinase kinase STE11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Dcr2p phosphatase destabilizes Sic1p in Saccharomyces cerevisiae. Pathak R, et al. Biochem Biophys Res Commun, 2007 Sep 28. PMID 17673172, Free PMC Article
    2. Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae. Pathak R, et al. Eukaryot Cell, 2004 Dec. PMID 15590836, Free PMC Article
    3. Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae. Bogomolnaya LM, et al. Curr Genet, 2006 Jun. PMID 16552603
    4. Golgi membrane protein Erd1 Is essential for recycling a subset of Golgi glycosyltransferases. Sardana R, et al. Elife, 2021 Nov 25. PMID 34821548, Free PMC Article
    5. A genome-wide immunodetection screen in S. cerevisiae uncovers novel genes involved in lysosomal vacuole function and morphology. Ricarte F, et al. PLoS One, 2011. PMID 21912603, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the Dcr2p phosphatase functionally and physically interacts with Sic1p. Over-expression of Dcr2p destabilizes Sic1p and leads to phenotypes associated with destabilized Sic1p, such as genome instability
      Title: The Dcr2p phosphatase destabilizes Sic1p in Saccharomyces cerevisiae.
    2. Overexpression of DCR2, but not of a catalytically inactive DCR2 allele, significantly delays HAC1 splicing and sensitizes cells to the UPR. Furthermore, Dcr2 physically interacts in vivo with Ire1-S840E,S841E, and de-phosphorylates Ire1 in vitro.
      Title: Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae.
    3. Hym1p requires Dcr2p(a phosphatase)and Gid8p (involved in protein degradation) to promote the transition from the G1 to S phase of the cell cycle
      Title: Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae.
    4. Gid8p (Dcr1p) and Dcr2p have roles in a common pathway to promote START completion in Saccharomyces cerevisiae
      Title: Gid8p (Dcr1p) and Dcr2p function in a common pathway to promote START completion in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoprotein phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoprotein phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of endoplasmic reticulum unfolded protein response IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of endoplasmic reticulum unfolded protein response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in traversing start control point of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 

    General protein information

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    Preferred Names
    phosphoprotein phosphatase
    NP_013465.1
    • Protein phosphatase; involved in downregulation of the unfolded protein response (UPR), at least in part through dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START; physically interacts with, dephosphorylates and destabilizes Sic1p; SWAT-GFP and mCherry fusion proteins localize to the vacuole

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      847388..849124 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182250.1 → NP_013465.1  TPA: phosphoprotein phosphatase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013465.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYZ8, Q05924
      UniProtKB/TrEMBL
      A0A8H4FA70, G2WJH8, N1NYP5
      Conserved Domains (1) summary
      cd07383
      Location:246 → 518
      MPP_Dcr2; Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05924.1

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