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    SES1 serine--tRNA ligase SES1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851587, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SES1
    Official Full Name
    serine--tRNA ligase SES1
    Primary source
    SGD:S000002430
    Locus tag
    YDR023W
    See related
    AllianceGenome:SGD:S000002430; FungiDB:YDR023W; VEuPathDB:YDR023W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables serine-tRNA ligase activity. Involved in seryl-tRNA aminoacylation. Located in cytoplasmic stress granule. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human SARS1 (seryl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SES1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (489508..490896)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Atg31p Neighboring gene tRNA-Val Neighboring gene ribosomal 40S subunit protein S11A Neighboring gene Nsi1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Shuffling of discrete tRNASer regions reveals differently utilized identity elements in yeast and methanogenic archaea. Gruic-Sovulj I, et al. J Mol Biol, 2006 Aug 4. PMID 16822522
    2. tRNA-dependent amino acid discrimination by yeast seryl-tRNA synthetase. Gruic-Sovulj I, et al. Eur J Biochem, 2002 Nov. PMID 12392560
    3. Characterization of yeast seryl-tRNA synthetase active site mutants with improved discrimination against substrate analogues. Landeka I, et al. Biochim Biophys Acta, 2000 Jul 14. PMID 11004561
    4. C-terminal truncation of yeast SerRS is toxic for Saccharomyces cerevisiae due to altered mechanism of substrate recognition. Lenhard B, et al. FEBS Lett, 1998 Nov 20. PMID 9845329
    5. Only one nucleotide insertion to the long variable arm confers an efficient serine acceptor activity upon Saccharomyces cerevisiae tRNA(Leu) in vitro. Himeno H, et al. J Mol Biol, 1997 May 16. PMID 9175855

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables aminoacyl-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables catalytic activity, acting on a tRNA IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of tRNA methylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in seryl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in seryl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in seryl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA aminoacylation for protein translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine--tRNA ligase SES1
    NP_010306.1
    • Cytosolic seryl-tRNA synthetase; class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate; copurifies with Abp140p in an RNA-dependent manner and stimulates 3-methylcytidine (m3C) modification of residue 32 of the tRNA anticodon loop of tRNA-Ser; interacts with peroxin Pex21p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      489508..490896
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180331.1 → NP_010306.1  TPA: serine--tRNA ligase SES1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010306.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VS09, P07284
      UniProtKB/TrEMBL
      A6ZXY7, B3LGP1, C7GLX3, C8Z4U3, G2WAD0, N1P628
      Conserved Domains (1) summary
      PLN02678
      Location:1 → 449
      PLN02678; seryl-tRNA synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07284.2

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