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    GPM3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854098, updated on 22-Aug-2024

    Summary

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    Official Symbol
    GPM3
    Primary source
    FungiDB:YOL056W
    Locus tag
    YOL056W
    See related
    SGD:S000005417; AllianceGenome:SGD:S000005417; VEuPathDB:YOL056W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable phosphoglycerate mutase activity. Predicted to be involved in glycolytic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in familial erythrocytosis 8. Orthologous to human BPGM (bisphosphoglycerate mutase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (223268..224179)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene argininosuccinate synthase Neighboring gene dipeptidyl-peptidase III Neighboring gene trifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase/thiaminase Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Time-dependent regulation analysis dissects shifts between metabolic and gene-expression regulation during nitrogen starvation in baker's yeast. van Eunen K, et al. FEBS J, 2009 Oct. PMID 19691496
    2. Parallel analysis of genetic selections using whole genome oligonucleotide arrays. Cho RJ, et al. Proc Natl Acad Sci U S A, 1998 Mar 31. PMID 9520439, Free PMC Article
    3. Characterization of the interaction between Rfa1 and Rad24 in Saccharomyces cerevisiae. Piya G, et al. PLoS One, 2015. PMID 25719602, Free PMC Article
    4. Investigation of two yeast genes encoding putative isoenzymes of phosphoglycerate mutase. Heinisch JJ, et al. Yeast, 1998 Feb. PMID 9544241
    5. Exposing the fitness contribution of duplicated genes. DeLuna A, et al. Nat Genet, 2008 May. PMID 18408719

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables intramolecular phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables phosphoglycerate mutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 

    General protein information

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    Preferred Names
    phosphoglycerate mutase family protein GPM3
    NP_014585.1
    • Nonfunctional homolog of Gpm1p phosphoglycerate mutase; if functional, would convert 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; GPM3 has a paralog, GPM2, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      223268..224179
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183311.1 → NP_014585.1  TPA: phosphoglycerate mutase family protein GPM3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014585.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W211, Q12326
      UniProtKB/TrEMBL
      A6ZNF4, B3LJ03, B5VRJ5, C7GK23, C8ZHQ7, G2WMH8, N1NY26
      Conserved Domains (1) summary
      COG0588
      Location:6 → 284
      GpmA; Phosphoglycerate mutase (BPG-dependent) [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12326.1

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