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    MRD1 RNA-binding ribosome biosynthesis protein MRD1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856228, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MRD1
    Official Full Name
    RNA-binding ribosome biosynthesis protein MRD1
    Primary source
    SGD:S000006316
    Locus tag
    YPR112C
    See related
    AllianceGenome:SGD:S000006316; FungiDB:YPR112C; VEuPathDB:YPR112C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA primary transcript binding activity. Involved in ribosomal small subunit biogenesis. Located in nucleolus. Part of 90S preribosome. Orthologous to human RBM19 (RNA binding motif protein 19). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See MRD1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (749256..751919, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase core subunit RPC40 Neighboring gene serine/threonine-protein kinase DBF20 Neighboring gene CDP-diacylglycerol--inositol 3-phosphatidyltransferase Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mrd1p is required for processing of pre-rRNA and for maintenance of steady-state levels of 40 S ribosomal subunits in yeast. Jin SB, et al. J Biol Chem, 2002 May 24. PMID 11884397
    2. Mrd1p is required for release of base-paired U3 snoRNA within the preribosomal complex. Lundkvist P, et al. Mol Cell Biol, 2009 Nov. PMID 19704003, Free PMC Article
    3. Evolutionary conservation of the ribosomal biogenesis factor Rbm19/Mrd1: implications for function. Kallberg Y, et al. PLoS One, 2012. PMID 22984444, Free PMC Article
    4. Linker 2 of the eukaryotic pre-ribosomal processing factor Mrd1p is an essential interdomain functionally coupled to upstream RNA Binding Domain 2 (RBD2). Lackmann F, et al. PLoS One, 2017. PMID 28388671, Free PMC Article
    5. Mrd1p binds to pre-rRNA early during transcription independent of U3 snoRNA and is required for compaction of the pre-rRNA into small subunit processomes. Segerstolpe A, et al. Nucleic Acids Res, 2008 Aug. PMID 18586827, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. We propose that the dynamic U3 snoRNA interactions and Mrd1 are essential for establishing the structure of the central core of 18S rRNA that is required for processing and 40S subunit function.
      Title: Maturation of the 90S pre-ribosome requires Mrd1 dependent U3 snoRNA and 35S pre-rRNA structural rearrangements.
    2. conclude that Linker 2 has an essential role for Mrd1p beyond just providing a defined length between RBD2 and RBD3
      Title: Linker 2 of the eukaryotic pre-ribosomal processing factor Mrd1p is an essential interdomain functionally coupled to upstream RNA Binding Domain 2 (RBD2).
    3. Mrd1p coordinates key events in biosynthesis of small ribosome subunits.
      Title: Mrd1p is required for release of base-paired U3 snoRNA within the preribosomal complex.
    4. Mrd1p is required for establishing productive structures within the 90S preribosomal complex.
      Title: Mrd1p binds to pre-rRNA early during transcription independent of U3 snoRNA and is required for compaction of the pre-rRNA into small subunit processomes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rRNA primary transcript binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in small-subunit processome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    part_of 90S preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding ribosome biosynthesis protein MRD1
    NP_015437.1
    • Essential conserved small ribosomal subunit (40s) synthesis factor; component of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains and binds to the pre-rRNA at two sites within the 18S region

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      749256..751919 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184209.1 → NP_015437.1  TPA: RNA-binding ribosome biosynthesis protein MRD1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015437.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4B1, Q06106
      UniProtKB/TrEMBL
      A6ZWZ3, N1NW41
      Conserved Domains (6) summary
      COG0724
      Location:222 → 612
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12568
      Location:532 → 603
      RRM3_MRD1; RNA recognition motif 3 (RRM3) found in yeast multiple RNA-binding domain-containing protein 1 (MRD1) and similar proteins
      cd12570
      Location:763 → 837
      RRM5_MRD1; RNA recognition motif 5 (RRM5) found in yeast multiple RNA-binding domain-containing protein 1 (MRD1) and similar proteins
      cd12315
      Location:2 → 92
      RRM1_RBM19_MRD1; RNA recognition motif 1 (RRM1) found in RNA-binding protein 19 (RBM19), yeast multiple RNA-binding domain-containing protein 1 (MRD1) and similar proteins
      cd12319
      Location:663 → 746
      RRM4_MRD1; RNA recognition motif 4 (RRM4) found in yeast multiple RNA-binding domain-containing protein 1 (MRD1) and similar proteins
      cd12566
      Location:343 → 421
      RRM2_MRD1; RNA recognition motif 2 (RRM2) found in yeast multiple RNA-binding domain-containing protein 1 (MRD1) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06106.1

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