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    PCI8 Pci8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854739, updated on 28-Oct-2024

    Summary

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    Official Symbol
    PCI8
    Official Full Name
    Pci8p
    Primary source
    SGD:S000001333
    Locus tag
    YIL071C
    See related
    AllianceGenome:SGD:S000001333; FungiDB:YIL071C; VEuPathDB:YIL071C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CSN11; YIH1; YIL071W
    Summary
    Involved in protein deneddylation. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Oct 2024]
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    Genomic context

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    See PCI8 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (228660..229994, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Spo22p Neighboring gene Hop1p Neighboring gene Mam33p Neighboring gene ribosomal 40S subunit protein S24B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits. Shalev A, et al. J Biol Chem, 2001 Sep 14. PMID 11457827
    2. The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae. Licursi V, et al. FEBS J, 2014 Jan. PMID 24164706
    3. Conservation of the COP9/signalosome in budding yeast. Wee S, et al. BMC Genet, 2002 Aug 20. PMID 12186635, Free PMC Article
    4. COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. Maytal-Kivity V, et al. EMBO Rep, 2002 Dec. PMID 12446563, Free PMC Article
    5. The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes. Maytal-Kivity V, et al. Int J Biochem Cell Biol, 2003 May. PMID 12672462

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COP9 signalosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of COP9 signalosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pci8p
    NP_085069.3
    • Possible shared subunit of Cop9 signalosome (CSN) and eIF3; binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      228660..229994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179421.3 → NP_085069.3  TPA: Pci8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_085069.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVL3, P40512
      UniProtKB/TrEMBL
      A6ZVK2, B3LTS3, C7GKK2, C8ZAH5, G2WG77, N1P4H7
      Conserved Domains (1) summary
      smart00088
      Location:296 → 387
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40512.1

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