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    rpt4 proteasome regulatory subunit Rpt4 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539189, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rpt4
    Official Full Name
    proteasome regulatory subunit Rpt4
    Primary source
    PomBase:SPCC1682.16
    Locus tag
    SPOM_SPCC1682.16
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rpt4 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    2
    Sequence:
    Chromosome: III; NC_003421.2 (405601..407595)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene PX/PXA domain protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Rab GTPase-binding protein Neighboring gene condensin complex non-SMC subunit Cnd2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 19S proteasome regulates subtelomere silencing and facultative heterochromatin formation in fission yeast. Seo HD, et al. Curr Genet, 2018 Jun. PMID 29214404
    2. Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach. Lasker K, et al. Proc Natl Acad Sci U S A, 2012 Jan 31. PMID 22307589, Free PMC Article
    3. Structure of the 26S proteasome from Schizosaccharomyces pombe at subnanometer resolution. Bohn S, et al. Proc Natl Acad Sci U S A, 2010 Dec 7. PMID 21098295, Free PMC Article
    4. Suppressor screening reveals common kleisin-hinge interaction in condensin and cohesin, but different modes of regulation. Xu X, et al. Proc Natl Acad Sci U S A, 2019 May 28. PMID 31072933, Free PMC Article
    5. The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast. Seo HD, et al. J Biol Chem, 2017 Oct 13. PMID 28784663, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP hydrolysis activity NAS
    Non-traceable Author Statement
    more info
    		  
    enables proteasome-activating activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables proteasome-activating activity ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of RNA polymerase II transcription preinitiation complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    part_of cytosolic proteasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus HDA PubMed 
    part_of proteasome regulatory particle, base subcomplex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle, base subcomplex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    proteasome regulatory subunit Rpt4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      405601..407595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022802.3 → NP_587809.2  proteasome regulatory subunit Rpt4 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_587809.2

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74445, Q9Y7R2
      Conserved Domains (3) summary
      COG1222
      Location:1 → 386
      RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]
      pfam00004
      Location:169 → 302
      AAA; ATPase family associated with various cellular activities (AAA)
      pfam13191
      Location:136 → 190
      AAA_16; AAA ATPase domain
    Nucleotide Protein
    Heading Accession and Version

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