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    BDF2 Bdf2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851488, updated on 17-May-2024

    Summary

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    Gene symbol
    BDF2
    Gene description
    Bdf2p
    Primary source
    FungiDB:YDL070W
    Locus tag
    YDL070W
    See related
    SGD:S000002228; AllianceGenome:SGD:S000002228; VEuPathDB:YDL070W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables TFIID-class transcription factor complex binding activity; core promoter sequence-specific DNA binding activity; and lysine-acetylated histone binding activity. Involved in negative regulation of heterochromatin assembly. Located in cell periphery. Human ortholog(s) of this gene implicated in juvenile myoclonic epilepsy; lymphoma (multiple); male infertility (multiple); and photosensitivity disease. Orthologous to human BRD2 (bromodomain containing 2); BRD3 (bromodomain containing 3); and BRDT (bromodomain testis associated). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See BDF2 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (331024..332940)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ahk1p Neighboring gene Yet3p Neighboring gene Cbs1p Neighboring gene cytochrome c oxidase subunit VIIa

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Disruption and phenotypic analysis of six novel genes from chromosome IV of Saccharomyces cerevisiae reveal YDL060w as an essential gene for vegetative growth. Casalone E, et al. Yeast, 1999 Nov. PMID 10572265
    2. BET family members Bdf1/2 modulate global transcription initiation and elongation in Saccharomyces cerevisiae. Donczew R, et al. Elife, 2021 Jun 17. PMID 34137374, Free PMC Article
    3. Interplay between BDF1 and BDF2 and their roles in regulating the yeast salt stress response. Fu J, et al. FEBS J, 2013 May. PMID 23452060
    4. Stress-induced nuclear RNA degradation pathways regulate yeast bromodomain factor 2 to promote cell survival. Roy K, et al. PLoS Genet, 2014 Sep. PMID 25232960, Free PMC Article
    5. NuA4-directed chromatin transactions throughout the Saccharomyces cerevisiae genome. Durant M, et al. Mol Cell Biol, 2007 Aug. PMID 17526728, Free PMC Article

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mitochondrial dysfunctions caused by BDF1 deletion are restored by overexpression of BDF2 under salt stress conditions in yeast.
      Title: Interplay between BDF1 and BDF2 and their roles in regulating the yeast salt stress response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables TFIID-class transcription factor complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables core promoter sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysine-acetylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysine-acetylated histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of heterochromatin formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sporulation resulting in formation of a cellular spore IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bdf2p
    NP_010213.1
    • Protein involved in transcription initiation; acts at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p; protein abundance increases in response to DNA replication stress; BDF2 has a paralog, BDF1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      331024..332940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180129.1 → NP_010213.1  TPA: Bdf2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010213.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRS8, Q07442
      UniProtKB/TrEMBL
      A0A8H8UML4, B5VFJ8, N1P468
      Conserved Domains (4) summary
      COG5076
      Location:55 → 378
      COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]
      pfam15619
      Location:472 → 537
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
      pfam17035
      Location:521 → 576
      BET; Bromodomain extra-terminal - transcription regulation
      cl02556
      Location:344 → 419
      Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07442.1

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