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    cdc10 DNA-binding transcription factor, MBF transcription factor complex subunit Cdc10 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540234, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cdc10
    Official Full Name
    DNA-binding transcription factor, MBF transcription factor complex subunit Cdc10
    Primary source
    PomBase:SPBC336.12c
    Locus tag
    SPOM_SPBC336.12C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cdc10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (2760741..2763800, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene protein Spc24 Neighboring gene RNA polymerase I general transcription initiation factor subunit Rrn7 Neighboring gene putative translation elongation factor eIF5A Neighboring gene GARP complex subunit Vps52 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene endopeptidase catalytic subunit Neighboring gene PAN complex subunit Ppk26

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spindle pole body duplication in fission yeast occurs at the G1/S boundary but maturation is blocked until exit from S by an event downstream of cdc10+. Uzawa S, et al. Mol Biol Cell, 2004 Dec. PMID 15385623, Free PMC Article
    2. Cdc18 transcription and proteolysis couple S phase to passage through mitosis. Baum B, et al. EMBO J, 1998 Oct 1. PMID 9755169, Free PMC Article
    3. The role of proteolysis in cell cycle progression in Schizosaccharomyces pombe. Yamano H, et al. EMBO J, 1996 Oct 1. PMID 8895572, Free PMC Article
    4. Fission yeast cut5+, required for S phase onset and M phase restraint, is identical to the radiation-damage repair gene rad4+. Saka Y, et al. Cell, 1993 Jul 30. PMID 8343962
    5. cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis. Hofmann JF, et al. EMBO J, 1994 Jan 15. PMID 8313888, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that Chk1 phosphorylates Cdc10 and inactivates MluI-binding factor (MBF)-dependent transcription.
      Title: The DNA damage and the DNA replication checkpoints converge at the MBF transcription factor.
    2. MBF dependent transcription remains active when Yox1 is phosphorylated and continues until cells are able to overcome this challenge
      Title: Yox1 links MBF-dependent transcription to completion of DNA synthesis.
    3. Results show that in the fission yeast Schizosaccharomyces pombe, the replication checkpoint regulates the entire G(1)/S transcriptional program by directly regulating Cdc10 subunit of MBF, the G(1)/S transcription factor.
      Title: The DNA replication checkpoint directly regulates MBF-dependent G1/S transcription.
    4. identified a mechanism by which Cdc10p controls rDNA gene expression, therefore linking the cell cycle with cellular growth
      Title: Pol5p, a novel binding partner to Cdc10p in fission yeast involved in rRNA production.
    5. There may be an S-phase-specific inhibitor of spindle pole body maturation whose expression is under control of cdc10(+)
      Title: Spindle pole body duplication in fission yeast occurs at the G1/S boundary but maturation is blocked until exit from S by an event downstream of cdc10+.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    contributes_to RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables promoter-specific chromatin binding EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of G1/S transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MBF transcription complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    part_of MBF transcription complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of MBF transcription complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm HDA PubMed 
    is_active_in nucleus EXP
    Inferred from Experiment
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcription factor, MBF transcription factor complex subunit Cdc10

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      2760741..2763800 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001022050.3 → NP_596132.1  DNA-binding transcription factor, MBF transcription factor complex subunit Cdc10 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_596132.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P01129, Q9UU04
      Conserved Domains (4) summary
      cd00204
      Location:387 → 519
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam04383
      Location:82 → 150
      KilA-N; KilA-N domain
      pfam12796
      Location:449 → 514
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:390 → 424
      ANK; ANK repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version

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