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    IVY1 Ivy1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851815, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IVY1
    Official Full Name
    Ivy1p
    Primary source
    SGD:S000002637
    Locus tag
    YDR229W
    See related
    AllianceGenome:SGD:S000002637; FungiDB:YDR229W; VEuPathDB:YDR229W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phospholipid binding activity. Involved in vacuole fusion, non-autophagic. Located in fungal-type vacuole membrane and membrane raft. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See IVY1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (924785..926146)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene chromatin-silencing protein SIR4 Neighboring gene Pcf11p Neighboring gene Cox20p Neighboring gene 5-aminolevulinate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast Ivy1p Is a Putative I-BAR-domain Protein with pH-sensitive Filament Forming Ability in vitro. Itoh Y, et al. Cell Struct Funct, 2016. PMID 26657738
    2. A novel phospholipid-binding protein from the yeast Saccharomyces cerevisiae with dual binding specificities for the transport GTPase Ypt7p and the Sec1-related Vps33p. Lazar T, et al. Eur J Cell Biol, 2002 Dec. PMID 12553664
    3. Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor. Malia PC, et al. Proc Natl Acad Sci U S A, 2018 May 1. PMID 29674454, Free PMC Article
    4. Yck3 casein kinase-mediated phosphorylation determines Ivy1 localization and function at endosomes and the vacuole. Grziwa S, et al. J Cell Sci, 2023 Jun 15. PMID 37259913
    5. Ivy1 is a negative regulator of Gtr-dependent TORC1 activation. Varlakhanova NV, et al. J Cell Sci, 2018 Sep 7. PMID 30097557, Free PMC Article

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ivy1 colocalizes with Gtr1 and Gtr2, a heterodimer of small GTPases that are part of the EGO complex.
      Title: Ivy1 is a negative regulator of Gtr-dependent TORC1 activation.
    2. data suggest that Ivy1 modulates Fab1-mediated PI-3,5-P2 synthesis during membrane stress and may allow adjustment of the vacuole membrane environment.
      Title: Control of vacuole membrane homeostasis by a resident PI-3,5-kinase inhibitor.
    3. pH-sensitive polymer forming ability and the functional conservation of Ivy1p in eukaryotic cells
      Title: Yeast Ivy1p Is a Putative I-BAR-domain Protein with pH-sensitive Filament Forming Ability in vitro.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in vacuole fusion, non-autophagic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vacuole fusion, non-autophagic IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in vacuole fusion, non-autophagic IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuole fusion, non-autophagic IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in fungal-type vacuole membrane HDA PubMed 
    is_active_in fungal-type vacuole membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vacuolar membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ivy1p
    NP_010515.3
    • Phospholipid-binding protein that interacts with both Ypt7p and Vps33p; may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase; contains a putative inverse BAR (I-BAR) domain that can mold lipid bilayer membranes into protrusions

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      924785..926146
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180537.3 → NP_010515.3  TPA: Ivy1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010515.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSL1, Q04934
      UniProtKB/TrEMBL
      A6ZYI3, B3LG58, C7GVC3, C8Z5E0, G2WAX4, N1P509
      Conserved Domains (1) summary
      cl01115
      Location:201 → 251
      BMFP; Membrane fusogenic activity
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q04934.1

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