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    RPF1 rRNA-binding ribosome biosynthesis protein RPF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856488, updated on 9-Jun-2024

    Summary

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    Gene symbol
    RPF1
    Gene description
    rRNA-binding ribosome biosynthesis protein RPF1
    Primary source
    FungiDB:YHR088W
    Locus tag
    YHR088W
    See related
    SGD:S000001130; AllianceGenome:SGD:S000001130; VEuPathDB:YHR088W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rRNA primary transcript binding activity. Involved in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and ribosomal large subunit export from nucleus. Located in nucleolus. Part of preribosome, large subunit precursor. Orthologous to human RPF1 (ribosome production factor 1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RPF1 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (281495..282382)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rtc3p Neighboring gene H/ACA snoRNP pseudouridylase subunit GAR1 Neighboring gene histone acetyltransferase YNG2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Kap120 functions as a nuclear import receptor for ribosome assembly factor Rpf1 in yeast. Caesar S, et al. Mol Cell Biol, 2006 Apr. PMID 16581791, Free PMC Article
    2. Functional analysis in yeast of the Brix protein superfamily involved in the biogenesis of ribosomes. Bogengruber E, et al. FEMS Yeast Res, 2003 Mar. PMID 12702244
    3. The sigma(70)-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis. Wehner KA, et al. Mol Cell, 2002 Feb. PMID 11864606
    4. Mak5 and Ebp2 act together on early pre-60S particles and their reduced functionality bypasses the requirement for the essential pre-60S factor Nsa1. Pratte D, et al. PLoS One, 2013. PMID 24312670, Free PMC Article
    5. Visualizing the Assembly Pathway of Nucleolar Pre-60S Ribosomes. Kater L, et al. Cell, 2017 Dec 14. PMID 29245012, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KAP120 functions as a nuclear import receptor for ribosome assembly factor RPF1.
      Title: Kap120 functions as a nuclear import receptor for ribosome assembly factor Rpf1 in yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA primary transcript binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA primary transcript binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of 5.8S rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of LSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of preribosome, large subunit precursor HDA PubMed 
    part_of preribosome, large subunit precursor IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of preribosome, large subunit precursor IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    rRNA-binding ribosome biosynthesis protein RPF1
    NP_011956.1
    • Protein involved in assembly and export of the large ribosomal subunit; nucleolar protein; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      281495..282382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179218.1 → NP_011956.1  TPA: rRNA-binding ribosome biosynthesis protein RPF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011956.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL40, P38805
      UniProtKB/TrEMBL
      A0A6A5PTV6, A6ZSZ8, B3LSK6, B5VK19, C7GWV2, C8Z9N3, G2WFG3, N1P9E4
      Conserved Domains (1) summary
      COG2136
      Location:92 → 277
      IMP4; rRNA maturation protein Rpf1, contains Brix/IMP4 (anticodon-binding) domain [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    5Z3G_O.1
    6EM1_x.1
    6EM3_x.1
    6EM4_x.1
    6EM5_x.1
    P38805.1

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