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    CWC22 U2-type spliceosomal complex subunit CWC22 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853195, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CWC22
    Official Full Name
    U2-type spliceosomal complex subunit CWC22
    Primary source
    SGD:S000003510
    Locus tag
    YGR278W
    See related
    AllianceGenome:SGD:S000003510; FungiDB:YGR278W; VEuPathDB:YGR278W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable RNA binding activity. Involved in mRNA splicing, via spliceosome. Part of U2-type spliceosomal complex. Orthologous to human CWC22 (CWC22 spliceosome associated protein homolog). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See CWC22 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1046731..1048464)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Rnh70p Neighboring gene putative pantetheine-phosphate adenylyltransferase Neighboring gene putative family 17 glucosidase Neighboring gene telomerase inhibitor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Postcatalytic spliceosome structure reveals mechanism of 3'-splice site selection. Wilkinson ME, et al. Science, 2017 Dec 8. PMID 29146871, Free PMC Article
    2. Molecular architecture of the Saccharomyces cerevisiae activated spliceosome. Rauhut R, et al. Science, 2016 Sep 23. PMID 27562955
    3. Splicing factor Cwc22 is required for the function of Prp2 and for the spliceosome to escape from a futile pathway. Yeh TC, et al. Mol Cell Biol, 2011 Jan. PMID 20956557, Free PMC Article
    4. Decrypting the Information Exchange Pathways across the Spliceosome Machinery. Saltalamacchia A, et al. J Am Chem Soc, 2020 May 6. PMID 32275149, Free PMC Article
    5. A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis. Minaker SW, et al. Cell Cycle, 2021 Jul. PMID 34180355, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the absence of Cwc22, Prp2 can bind to the spliceosome but is dissociated upon ATP hydrolysis without promoting the release of SF3a/b.
      Title: Splicing factor Cwc22 is required for the function of Prp2 and for the spliceosome to escape from a futile pathway.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of U2-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    U2-type spliceosomal complex subunit CWC22
    NP_011794.3
    • Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1046731..1048464
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181407.3 → NP_011794.3  TPA: U2-type spliceosomal complex subunit CWC22 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011794.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV55, P53333
      UniProtKB/TrEMBL
      A6ZUT4, G2WF01, N1P6A5
      Conserved Domains (2) summary
      smart00543
      Location:24 → 204
      MIF4G; Middle domain of eukaryotic initiation factor 4G (eIF4G)
      pfam02847
      Location:291 → 398
      MA3; MA3 domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53333.1

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