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    YRB2 Yrb2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854747, updated on 17-May-2024

    Summary

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    Gene symbol
    YRB2
    Gene description
    Yrb2p
    Primary source
    FungiDB:YIL063C
    Locus tag
    YIL063C
    See related
    SGD:S000001325; AllianceGenome:SGD:S000001325; VEuPathDB:YIL063C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to contribute to GTPase activator activity. Involved in protein export from nucleus and ribosomal small subunit export from nucleus. Located in cytosol and nucleus. Orthologous to human RANBP3 (RAN binding protein 3) and RANBP3L (RAN binding protein 3 like). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YRB2 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (242761..243744, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Fis1p Neighboring gene Efm4p Neighboring gene Arc15p Neighboring gene U1 snRNP complex subunit SNP1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ribotoxin α-sarcin can cleave the sarcin/ricin loop on late 60S pre-ribosomes. Olombrada M, et al. Nucleic Acids Res, 2020 Jun 19. PMID 32365182, Free PMC Article
    2. Requirements for the nuclear export of the small ribosomal subunit. Moy TI, et al. J Cell Sci, 2002 Jul 15. PMID 12082158
    3. Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae. Seiser RM, et al. Genetics, 2006 Oct. PMID 16888326, Free PMC Article
    4. Disruption of the YRB2 gene retards nuclear protein export, causing a profound mitotic delay, and can be rescued by overexpression of XPO1/CRM1. Noguchi E, et al. J Biochem, 1999 Mar. PMID 10050047
    5. A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein export. Taura T, et al. Proc Natl Acad Sci U S A, 1998 Jun 23. PMID 9636166, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in NLS-bearing protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal small subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Yrb2p
    NP_012201.1
    • hypothetical protein; involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; relocalizes to the cytosol in response to hypoxia; not essential for viability

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      242761..243744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179413.1 → NP_012201.1  TPA: Yrb2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012201.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVM1, P40517
      UniProtKB/TrEMBL
      A0A8H4BZC1, B3LTR6, C8ZAI5, N1P101
      Conserved Domains (1) summary
      smart00160
      Location:193 → 321
      RanBD; Ran-binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40517.1

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