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    CFT2 cleavage polyadenylation factor subunit CFT2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850806, updated on 17-May-2024

    Summary

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    Gene symbol
    CFT2
    Gene description
    cleavage polyadenylation factor subunit CFT2
    Primary source
    FungiDB:YLR115W
    Locus tag
    YLR115W
    See related
    SGD:S000004105; AllianceGenome:SGD:S000004105; VEuPathDB:YLR115W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    YDH1
    Summary
    Enables RNA binding activity. Involved in mRNA polyadenylation and pre-mRNA cleavage required for polyadenylation. Part of mRNA cleavage and polyadenylation specificity factor complex. Orthologous to human CPSF2 (cleavage and polyadenylation specific factor 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See CFT2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (377985..380564)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene tRNA-Arg Neighboring gene Avl9p Neighboring gene mRNA splicing protein MSL5 Neighboring gene Clf1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A serendipitous discovery that in situ proteolysis is essential for the crystallization of yeast CPSF-100 (Ydh1p). Mandel CR, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Oct 1. PMID 17012808, Free PMC Article
    2. Cleavage factor II of Saccharomyces cerevisiae contains homologues to subunits of the mammalian Cleavage/ polyadenylation specificity factor and exhibits sequence-specific, ATP-dependent interaction with precursor RNA. Zhao J, et al. J Biol Chem, 1997 Apr 18. PMID 9099738
    3. The C terminus of Pcf11 forms a novel zinc-finger structure that plays an essential role in mRNA 3'-end processing. Yang F, et al. RNA, 2017 Jan. PMID 27780845, Free PMC Article
    4. The conserved histone deacetylase Rpd3 and its DNA binding subunit Ume6 control dynamic transcript architecture during mitotic growth and meiotic development. Lardenois A, et al. Nucleic Acids Res, 2015 Jan. PMID 25477386, Free PMC Article
    5. A multisubunit 3' end processing factor from yeast containing poly(A) polymerase and homologues of the subunits of mammalian cleavage and polyadenylation specificity factor. Preker PJ, et al. EMBO J, 1997 Aug 1. PMID 9303317, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. crystal structure of yeast protein CPSF-100 (Ydh1) at 2.5 A resolution
      Title: Polyadenylation factor CPSF-73 is the pre-mRNA 3'-end-processing endonuclease.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of mRNA cleavage and polyadenylation specificity factor complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cleavage polyadenylation factor subunit CFT2
    NP_013216.1
    • Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      377985..380564
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182002.1 → NP_013216.1  TPA: cleavage polyadenylation factor subunit CFT2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013216.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VYB3, Q12102, Q7LGW6
      UniProtKB/TrEMBL
      A0A8H4F8L9, A7A117, B3LT80, B5VN51, C7GQD6, N1P159
      Conserved Domains (3) summary
      smart01027
      Location:254 → 372
      Beta-Casp; Beta-Casp domain
      pfam13299
      Location:732 → 856
      CPSF100_C; Cleavage and polyadenylation factor 2 C-terminal
      pfam16661
      Location:19 → 211
      Lactamase_B_6; Metallo-beta-lactamase superfamily domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12102.1

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