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    XBP1 Xbp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854706, updated on 17-May-2024

    Summary

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    Gene symbol
    XBP1
    Gene description
    Xbp1p
    Primary source
    FungiDB:YIL101C
    Locus tag
    YIL101C
    See related
    SGD:S000001363; AllianceGenome:SGD:S000001363
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in cellular response to oxidative stress; negative regulation of transcription by RNA polymerase II; and positive regulation of histone deacetylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See XBP1 in Genome Data Viewer
    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (175307..177250, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene tRNA-Thr Neighboring gene glucan 1,4-alpha-glucosidase Neighboring gene Fmc1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xbp1, a stress-induced transcriptional repressor of the Saccharomyces cerevisiae Swi4/Mbp1 family. Mai B, et al. Mol Cell Biol, 1997 Nov. PMID 9343412, Free PMC Article
    2. Characterization of global gene expression during assurance of lifespan extension by caloric restriction in budding yeast. Choi KM, et al. Exp Gerontol, 2013 Dec. PMID 24126084
    3. CLN1 and its repression by Xbp1 are important for efficient sporulation in budding yeast. Mai B, et al. Mol Cell Biol, 2000 Jan. PMID 10611226, Free PMC Article
    4. Global Promoter Targeting of a Conserved Lysine Deacetylase for Transcriptional Shutoff during Quiescence Entry. McKnight JN, et al. Mol Cell, 2015 Sep 3. PMID 26300265, Free PMC Article
    5. Identification of target genes of a yeast transcriptional repressor. Mai B, et al. Methods Mol Biol, 2006. PMID 16264235

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Further global analysis revealed that Xbp1 represses 15% of all yeast genes as they enter the quiescent state and over 500 of these transcripts contain Xbp1 binding sites in their promoters
      Title: Xbp1 directs global repression of budding yeast transcription during the transition to quiescence and is important for the longevity and reversibility of the quiescent state.
    2. A role for Xbp1 in DSB repair via NHEJ through regulation of histone H4 acetylation.
      Title: Xbp1-mediated histone H4 deacetylation contributes to DNA double-strand break repair in yeast.
    3. the binding site for Xbp1 is present in the target genes of Swi4 and Mbp1 and is conserved phylogenetically
      Title: Identification of target genes of a yeast transcriptional repressor.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding HDA PubMed 
    enables transcription regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G1 to G0 transition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to glucose starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to nitrogen starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MBF transcription complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SBF transcription complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Xbp1p
    NP_012165.1
    • Transcriptional repressor; binds promoter sequences of cyclin genes, CYS3, and SMF2; not expressed during log phase of growth, but induced by stress or starvation during mitosis, and late in meiosis; represses 15% of all yeast genes as cells transition to quiescence; important for maintaining G1 arrest and for longevity of quiescent cells; member of Swi4p/Mbp1p family; phosphorylated by Cdc28p; relative distribution to nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      175307..177250 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179449.1 → NP_012165.1  TPA: Xbp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012165.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVI7, P40489, Q12688
      UniProtKB/TrEMBL
      A0A8H4C096, A6ZVH7, B3LTU7, C7GKM7, C8ZAE8, N1P0X1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40489.1

    Gene LinkOut

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