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    BSD2 Bsd2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852593, updated on 2-Nov-2024

    Summary

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    Official Symbol
    BSD2
    Official Full Name
    Bsd2p
    Primary source
    SGD:S000000494
    Locus tag
    YBR290W
    See related
    AllianceGenome:SGD:S000000494; FungiDB:YBR290W; VEuPathDB:YBR290W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in metal ion transport; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum and fungal-type vacuole membrane. Orthologous to human NDFIP1 (Nedd4 family interacting protein 1) and NDFIP2 (Nedd4 family interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See BSD2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (782591..783556)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Apm3p Neighboring gene Snf5p Neighboring gene Ctp1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the resistance to adriamycin acquired by overexpression of BSD2 might be partially explained by down-regulation of Smf2
      Title: A novel role for Bsd2 in the resistance of yeast to adriamycin.
    2. Bsd2 provides an alternative ubiquitination mechanism for Cps1, Phm5 and other proteins
      Title: Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in metal ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein targeting to vacuole IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vacuolar transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole HDA PubMed 
    located_in fungal-type vacuole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in vacuole IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Bsd2p
    NP_009849.1
    • Heavy metal ion homeostasis protein; facilitates trafficking of Smf1p and Smf2p metal transporters to vacuole where they are degraded; acts as an adaptor protein with Rsp5p in the regulated endocytosis of Smf1p and is itself ubiquitylated by Rsp5p; controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      782591..783556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178638.1 → NP_009849.1  TPA: Bsd2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009849.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQT5, P38356
      UniProtKB/TrEMBL
      A6ZLM8, B3LMM3, B5VEN4, C7GMU2, D3UF37, G2W9U3, N1P8X2
      Conserved Domains (1) summary
      pfam10176
      Location:106 → 319
      DUF2370; Protein of unknown function (DUF2370)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38356.1

    Gene LinkOut

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