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    ASK10 Ask10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852989, updated on 17-May-2024

    Summary

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    Gene symbol
    ASK10
    Gene description
    Ask10p
    Primary source
    FungiDB:YGR097W
    Locus tag
    YGR097W
    See related
    SGD:S000003329; AllianceGenome:SGD:S000003329; VEuPathDB:YGR097W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    RGC2
    Summary
    Enables channel regulator activity. Involved in cellular protein catabolic process; cellular response to oxidative stress; and positive regulation of glycerol transport. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ASK10 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (678695..682135)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene exosome non-catalytic core subunit RRP46 Neighboring gene thiamine transporter TPC1 Neighboring gene separase Neighboring gene Tel2p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of ASK10 as a multicopy activator of Skn7p-dependent transcription of a HIS3 reporter gene. Page N, et al. Yeast, 1996 Mar 15. PMID 8904339
    2. Disentangling genetic and epigenetic determinants of ultrafast adaptation. Gjuvsland AB, et al. Mol Syst Biol, 2016 Dec 15. PMID 27979908, Free PMC Article
    3. Rgc2 Regulator of Glycerol Channel Fps1 Functions as a Homo- and Heterodimer with Rgc1. Lee J, et al. Eukaryot Cell, 2015 Jul. PMID 26024902, Free PMC Article
    4. Yeast Fps1 glycerol facilitator functions as a homotetramer. Beese-Sims SE, et al. Yeast, 2011 Dec. PMID 22030956, Free PMC Article
    5. MAPK Hog1 closes the S. cerevisiae glycerol channel Fps1 by phosphorylating and displacing its positive regulators. Lee J, et al. Genes Dev, 2013 Dec 1. PMID 24298058, Free PMC Article

    See all (70) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ASK10 was phosphorylated in response to stresses that lead to regulation of Fps1
      Title: Identification of positive regulators of the yeast fps1 glycerol channel.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables channel regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cellular response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of glycerol transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ask10p
    NP_011611.1
    • Regulator of the Fps1p glycerol channel; under nonstress conditions, binds to Fps1p to positively regulate glycerol transport; under osmotic stress, multiple phosphorylation by Hog1p causes Ask10p to dissociate from Fps1p; forms homodimers and heterodimerizes with paralog Rgc1p; phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; associates with RNA polymerase II holoenzyme

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      678695..682135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181226.1 → NP_011611.1  TPA: Ask10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011611.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUM9, P48361
      UniProtKB/TrEMBL
      A0A8H4FAA1, A6ZV79, B3LIC9, B5VJ44, C7GWW6
      Conserved Domains (1) summary
      cl17171
      Location:483 → 517
      PH-like; Pleckstrin homology-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P48361.2

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