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    FSH2 putative serine hydrolase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855262, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FSH2
    Official Full Name
    putative serine hydrolase
    Primary source
    SGD:S000004835
    Locus tag
    YMR222C
    See related
    AllianceGenome:SGD:S000004835; FungiDB:YMR222C; VEuPathDB:YMR222C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable carboxylic ester hydrolase activity. Located in cytoplasm. Orthologous to human OVCA2 (OVCA2 serine hydrolase domain containing). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See FSH2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (715638..716309, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene phosphomevalonate kinase Neighboring gene Fmp42p Neighboring gene ubiquitin-specific protease UBP8 Neighboring gene MRX complex nuclease subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-Throughput Screening of an Octanoic Acid Producer Strain Library Enables Detection of New Targets for Increasing Titers in Saccharomyces cerevisiae. Baumann L, et al. ACS Synth Biol, 2021 May 21. PMID 33979526
    2. FSH3 mediated cell death is dependent on NUC1 in Saccharomyces cerevisiae. Gowsalya R, et al. FEMS Yeast Res, 2019 May 1. PMID 30776074
    3. Synergistic computational and experimental proteomics approaches for more accurate detection of active serine hydrolases in yeast. Baxter SM, et al. Mol Cell Proteomics, 2004 Mar. PMID 14645503
    4. TFIID and Spt-Ada-Gcn5-acetyltransferase functions probed by genome-wide synthetic genetic array analysis using a Saccharomyces cerevisiae taf9-ts allele. Milgrom E, et al. Genetics, 2005 Nov. PMID 16118188, Free PMC Article
    5. A nuclear role for the DEAD-box protein Dbp5 in tRNA export. Lari A, et al. Elife, 2019 Aug 27. PMID 31453808, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative serine hydrolase
    NP_013949.1
    • Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      715638..716309 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182729.1 → NP_013949.1  TPA: putative serine hydrolase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013949.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W047, Q05015
      UniProtKB/TrEMBL
      B3LMB0, B5VPZ1, C8ZF86
      Conserved Domains (1) summary
      pfam03959
      Location:1 → 214
      FSH1; Serine hydrolase (FSH1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05015.1

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