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    ELP2 Elongator subunit ELP2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853114, updated on 17-May-2024

    Summary

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    Gene symbol
    ELP2
    Gene description
    Elongator subunit ELP2
    Primary source
    FungiDB:YGR200C
    Locus tag
    YGR200C
    See related
    SGD:S000003432; AllianceGenome:SGD:S000003432; VEuPathDB:YGR200C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KTI3; TOT2
    Summary
    Enables microtubule binding activity. Involved in protein urmylation; regulation of transcription by RNA polymerase II; and tRNA wobble uridine modification. Located in cytoplasm and nucleus. Part of elongator holoenzyme complex. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human ELP2 (elongator acetyltransferase complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ELP2 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (899904..902270, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Ypp1p Neighboring gene dolichyl-phosphate-mannose-protein mannosyltransferase PMT6 Neighboring gene uncharacterized protein Neighboring gene choline-phosphate cytidylyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular basis of tRNA recognition by the Elongator complex. Dauden MI, et al. Sci Adv, 2019 Jul. PMID 31309145, Free PMC Article
    2. Use of a Yeast tRNase Killer Toxin to Diagnose Kti12 Motifs Required for tRNA Modification by Elongator. Mehlgarten C, et al. Toxins (Basel), 2017 Sep 5. PMID 28872616, Free PMC Article
    3. The tRNA modification complex elongator regulates the Cdc42-dependent mitogen-activated protein kinase pathway that controls filamentous growth in yeast. Abdullah U, et al. Eukaryot Cell, 2009 Sep. PMID 19633267, Free PMC Article
    4. Intracellular expression of Kluyveromyces lactis toxin gamma subunit mimics treatment with exogenous toxin and distinguishes two classes of toxin-resistant mutant. Butler AR, et al. Yeast, 1991 Aug-Sep. PMID 1767590
    5. Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation. Rahl PB, et al. Mol Cell, 2005 Mar 18. PMID 15780940

    See all (117) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein urmylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA wobble uridine modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of elongator holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of elongator holoenzyme complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of elongator holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Elongator subunit ELP2
    NP_011716.3
    • Subunit of Elongator complex; binds to microtubules via conserved alkaline residues; has two seven-bladed WD40 beta propellers; Elongator complex is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      899904..902270 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181329.3 → NP_011716.3  TPA: Elongator subunit ELP2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011716.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUY2, E9P8V1, P42935
      UniProtKB/TrEMBL
      A0A8H4C369, B5VJE3, N1P629
      Conserved Domains (3) summary
      cd00200
      Location:52 → 413
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:62 → 102
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:554 → 786
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    6QK7_B.1
    P42935.1

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