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    OKP1 Okp1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853090, updated on 29-Jun-2024

    Summary

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    Gene symbol
    OKP1
    Gene description
    Okp1p
    Primary source
    FungiDB:YGR179C
    Locus tag
    YGR179C
    See related
    SGD:S000003411; AllianceGenome:SGD:S000003411; VEuPathDB:YGR179C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in attachment of spindle microtubules to kinetochore. Located in kinetochore. Part of COMA complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See OKP1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (853675..854895, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene alcohol O-acetyltransferase Neighboring gene Pbp1p Neighboring gene ribonucleotide-diphosphate reductase subunit RNR4 Neighboring gene tRNA-Leu

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Spindle checkpoint maintenance requires Ame1 and Okp1. Pot I, et al. Cell Cycle, 2005 Oct. PMID 16177574
    2. Changes in the localization of the Saccharomyces cerevisiae anaphase-promoting complex upon microtubule depolymerization and spindle checkpoint activation. Melloy PG, et al. Genetics, 2004 Jul. PMID 15280225, Free PMC Article
    3. Phosphorylation of centromeric histone H3 variant regulates chromosome segregation in Saccharomyces cerevisiae. Boeckmann L, et al. Mol Biol Cell, 2013 Jun. PMID 23637466, Free PMC Article
    4. Kinetochores generate microtubules with distal plus ends: their roles and limited lifetime in mitosis. Kitamura E, et al. Dev Cell, 2010 Feb 16. PMID 20159595, Free PMC Article
    5. The COMA complex is required for Sli15/INCENP-mediated correction of defective kinetochore attachments. Knockleby J, et al. Cell Cycle, 2009 Aug 15. PMID 19597337

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex.
      Title: Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex.
    2. Overexpression of OKP1 restores kinetochore localization of the mutant Ame1-4 protein, Sli15 localization is not restored and defective attachments are not corrected.
      Title: The COMA complex is required for Sli15/INCENP-mediated correction of defective kinetochore attachments.
    3. Ame1 and Okp1 are required for a sustained checkpoint arrest in the presence of mis-segregated chromosomes
      Title: Spindle checkpoint maintenance requires Ame1 and Okp1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of spindle microtubules to kinetochore IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of COMA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in kinetochore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Okp1p
    NP_011695.1
    • Outer kinetochore protein required for accurate chromosome segregation; component of COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) a kinetochore sub-complex which functions as a platform for kinetochore assembly; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-Q and fission yeast fta7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      853675..854895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181308.1 → NP_011695.1  TPA: Okp1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011695.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUW3, P53298
      UniProtKB/TrEMBL
      A0A8H4FBM9, G2WEQ9, N1P612
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53298.1

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