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    UTP6 snoRNA-binding rRNA-processing protein UTP6 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852060, updated on 2-Nov-2024

    Summary

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    Official Symbol
    UTP6
    Official Full Name
    snoRNA-binding rRNA-processing protein UTP6
    Primary source
    SGD:S000002857
    Locus tag
    YDR449C
    See related
    AllianceGenome:SGD:S000002857; FungiDB:YDR449C; VEuPathDB:YDR449C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables U3 snoRNA binding activity. Involved in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Orthologous to human UTP6 (UTP6 small subunit processome component). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See UTP6 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1357580..1358902, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal 40S subunit protein S17B Neighboring gene chromatin-binding transcription regulator ADA2 Neighboring gene ribosomal 40S subunit protein S18A Neighboring gene Yhp1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics. Champion EA, et al. Protein Eng Des Sel, 2009 Jul. PMID 19515729, Free PMC Article
    2. Mammalian HCA66 protein is required for both ribosome synthesis and centriole duplication. Bonnart C, et al. Nucleic Acids Res, 2012 Jul. PMID 22434888, Free PMC Article
    3. Integrative structural analysis of the UTPB complex, an early assembly factor for eukaryotic small ribosomal subunits. Zhang C, et al. Nucleic Acids Res, 2016 Sep 6. PMID 27330138, Free PMC Article
    4. A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing. Champion EA, et al. Mol Cell Biol, 2008 Nov. PMID 18725399, Free PMC Article
    5. The DEAD-box RNA helicase-like Utp25 is an SSU processome component. Charette JM, et al. RNA, 2010 Nov. PMID 20884785, Free PMC Article

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The interaction between the half-a-tetratricopeptide repeat (HAT) domain of Utp6 and a specific peptide in Utp21, is investigated.
      Title: A direct interaction between the Utp6 half-a-tetratricopeptide repeat domain and a specific peptide in Utp21 is essential for efficient pre-rRNA processing.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables U3 snoRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables snoRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables snoRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of 90S preribosome HDA PubMed 
    part_of Pwp2p-containing subcomplex of 90S preribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Pwp2p-containing subcomplex of 90S preribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of small-subunit processome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    snoRNA-binding rRNA-processing protein UTP6
    NP_010737.1
    • Nucleolar protein; component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1357580..1358902 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180757.1 → NP_010737.1  TPA: snoRNA-binding rRNA-processing protein UTP6 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010737.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VT74, Q02354, Q04115
      UniProtKB/TrEMBL
      A6ZZ40, B3LFL3, B5VGY0, C7GKP1, C8Z607, N1P7I7
      Conserved Domains (1) summary
      COG5191
      Location:1 → 440
      COG5191; Uncharacterized conserved protein, contains HAT (Half-A-TPR) repeat [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02354.2

    Gene LinkOut

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