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    lap2 aminopeptidase Lap2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2538917, updated on 18-Sep-2024

    Summary

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    Official Symbol
    lap2
    Official Full Name
    aminopeptidase Lap2
    Primary source
    PomBase:SPCC1322.05c
    Locus tag
    SPOM_SPCC1322.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    ppp85
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    Genomic context

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    See lap2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1293804..1296128, complement)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene 3' ssRNA-specific 3'-to-5' exonuclease Neighboring gene ncRNA Neighboring gene protein Pdx1 Neighboring gene TRP-like ion channel protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene UTP-glucose-1-phosphate uridylyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene karyopherin/importin beta family nuclear import signal receptor Kap113

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ESCRTs Cooperate with a Selective Autophagy Receptor to Mediate Vacuolar Targeting of Soluble Cargos. Liu XM, et al. Mol Cell, 2015 Sep 17. PMID 26365378
    2. Transcription and chromatin-based surveillance mechanism controls suppression of cryptic antisense transcription. Heo DH, et al. Cell Rep, 2021 Sep 7. PMID 34496258, Free PMC Article
    3. ORFeome cloning and global analysis of protein localization in the fission yeast Schizosaccharomyces pombe. Matsuyama A, et al. Nat Biotechnol, 2006 Jul. PMID 16823372
    4. The genome sequence of Schizosaccharomyces pombe. Wood V, et al. Nature, 2002 Feb 21. PMID 11859360
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables aminopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables epoxide hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloaminopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasm to vacuole targeting by the NVT pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peptide catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of NVT complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in fungal-type vacuole lumen IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in multivesicular body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    aminopeptidase Lap2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1293804..1296128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023123.3 → NP_588133.1  aminopeptidase Lap2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_588133.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O94544
      Conserved Domains (3) summary
      cd09599
      Location:6 → 450
      M1_LTA4H; Peptidase M1 family contains leukotriene A4 hydrolase
      TIGR02411
      Location:6 → 608
      leuko_A4_hydro; leukotriene A-4 hydrolase/aminopeptidase
      pfam09127
      Location:468 → 607
      Leuk-A4-hydro_C; Leukotriene A4 hydrolase, C-terminal
    Nucleotide Protein
    Heading Accession and Version

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