ECM33 Ecm33p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: ECM33
Official Full Name: Ecm33p
Primary source: SGD:S000000282
Locus tag: YBR078W
See related: AllianceGenome:SGD:S000000282; FungiDB:YBR078W; VEuPathDB:YBR078W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in fungal-type cell wall organization. Located in fungal-type cell wall and plasma membrane. [provided by Alliance of Genome Resources, Oct 2024]
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Chromosome II - NC_001134.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

Modulation of the cell wall protein Ecm33p in yeast Saccharomyces cerevisiae improves the production of small metabolites.
Title: Modulation of the cell wall protein Ecm33p in yeast Saccharomyces cerevisiae improves the production of small metabolites.
Study shows that Ecm33 is involved in regulating intracellular TORC1 signaling by facilitating efficient uptake of extracellular glucose, the most vital nutrient.
Title: Ecm33 is a novel factor involved in efficient glucose uptake for nutrition-responsive TORC1 signaling in yeast.
Ecm33 overproducing cells displayed phenotypes closely similar to those of the pmk1 knockout cell[review]
Title: [Cell surface protein Ecm33 is involved in negative feedback regulation of MAP kinase signalling and development of the in vivo real-time monitoring of MAP kinase signalling].
important for proper cell wall ultrastructure organization and, for the correct assembly of the mannoprotein outer layer of the cell wall.
Title: PST1 and ECM33 encode two yeast cell surface GPI proteins important for cell wall integrity.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cell wall organization	IEA Inferred from Electronic Annotation more info
involved_in fungal-type cell wall organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in fungal-type cell wall	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

NP_009634.2

GPI-anchored protein involved in efficient glucose uptake; possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p; ECM33 has a paralog, PST1, that arose from the whole genome duplication