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    ESF1 pre-rRNA-processing protein ESF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851969, updated on 29-Jun-2024

    Summary

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    Gene symbol
    ESF1
    Gene description
    pre-rRNA-processing protein ESF1
    Primary source
    FungiDB:YDR365C
    Locus tag
    YDR365C
    See related
    SGD:S000002773; AllianceGenome:SGD:S000002773; VEuPathDB:YDR365C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables RNA binding activity. Involved in rRNA processing. Located in nucleolus. Orthologous to human ESF1 (ESF1 nucleolar pre-rRNA processing protein homolog). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ESF1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1204497..1206383, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle lid subunit SEM1 Neighboring gene Cdc40p Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene Mor1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ESF1 is required for 18S rRNA synthesis in Saccharomyces cerevisiae. Peng WT, et al. Nucleic Acids Res, 2004. PMID 15056729, Free PMC Article
    2. The helicase Has1p is required for snoRNA release from pre-rRNA. Liang XH, et al. Mol Cell Biol, 2006 Oct. PMID 16908538, Free PMC Article
    3. Esf2p, a U3-associated factor required for small-subunit processome assembly and compaction. Hoang T, et al. Mol Cell Biol, 2005 Jul. PMID 15964808, Free PMC Article
    4. Nop9 is an RNA binding protein present in pre-40S ribosomes and required for 18S rRNA synthesis in yeast. Thomson E, et al. RNA, 2007 Dec. PMID 17956976, Free PMC Article
    5. Pwp2 mediates UTP-B assembly via two structurally independent domains. Boissier F, et al. Sci Rep, 2017 Jun 9. PMID 28600509, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in rRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    pre-rRNA-processing protein ESF1
    NP_010653.1
    • Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1204497..1206383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180673.1 → NP_010653.1  TPA: pre-rRNA-processing protein ESF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010653.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VSZ4, Q06344
      UniProtKB/TrEMBL
      A0A6A5PZ22, A6ZYW4, B3LFT7, C7GMH1, C8Z5S7, G2WBA2, N1P717
      Conserved Domains (1) summary
      COG5638
      Location:1 → 608
      COG5638; Uncharacterized conserved protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06344.1

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