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    LOA1 lysophosphatidic acid acyltransferase LOA1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856261, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LOA1
    Official Full Name
    lysophosphatidic acid acyltransferase LOA1
    Primary source
    SGD:S000006343
    Locus tag
    YPR139C
    See related
    AllianceGenome:SGD:S000006343; FungiDB:YPR139C; VEuPathDB:YPR139C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    VPS66
    Summary
    Enables lysophosphatidic acid acyltransferase activity. Involved in cellular triglyceride homeostasis and lipid droplet organization. Located in endoplasmic reticulum and lipid droplet. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See LOA1 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (813156..814058, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene tRNA-Asn Neighboring gene ammonium permease MEP3 Neighboring gene lysophosphatidylcholine acyltransferase Neighboring gene Kar3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lipids containing medium-chain fatty acids are specific to post-whole genome duplication Saccharomycotina yeasts. Froissard M, et al. BMC Evol Biol, 2015 May 28. PMID 26018144, Free PMC Article
    2. YPR139c/LOA1 encodes a novel lysophosphatidic acid acyltransferase associated with lipid droplets and involved in TAG homeostasis. Ayciriex S, et al. Mol Biol Cell, 2012 Jan. PMID 22090344, Free PMC Article
    3. Lipid particles/droplets of the yeast Saccharomyces cerevisiae revisited: lipidome meets proteome. Grillitsch K, et al. Biochim Biophys Acta, 2011 Dec. PMID 21820081, Free PMC Article
    4. Dissecting seipin function: the localized accumulation of phosphatidic acid at ER/LD junctions in the absence of seipin is suppressed by Sei1p(ΔNterm) only in combination with Ldb16p. Han S, et al. BMC Cell Biol, 2015 Dec 4. PMID 26637296, Free PMC Article
    5. Prevacuolar compartment morphology in vps mutants of Saccharomyces cerevisiae. Hedman JM, et al. Cell Biol Int, 2007 Oct. PMID 17543551

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loa1p is therefore a novel lysophosphatidic acid acyltransferase and plays a role in lipid droplets formation.
      Title: YPR139c/LOA1 encodes a novel lysophosphatidic acid acyltransferase associated with lipid droplets and involved in TAG homeostasis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 1-acylglycerol-3-phosphate O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid droplet organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein targeting to vacuole HMP PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lipid droplet IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lipid droplet IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lysophosphatidic acid acyltransferase LOA1
    NP_015465.1
    • Lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      813156..814058 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184236.1 → NP_015465.1  TPA: lysophosphatidic acid acyltransferase LOA1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015465.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4D7, Q06508
      UniProtKB/TrEMBL
      A6ZX16, B3LKA0, B5VTS6, C7GLJ9, C8ZJG2, G2WPV3, N1NVL6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06508.1

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