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    TOA1 transcription initiation factor IIA large subunit [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854369, updated on 29-Jun-2024

    Summary

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    Gene symbol
    TOA1
    Gene description
    transcription initiation factor IIA large subunit
    Primary source
    FungiDB:YOR194C
    Locus tag
    YOR194C
    See related
    SGD:S000005720; AllianceGenome:SGD:S000005720; VEuPathDB:YOR194C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables transcription coregulator activity. Contributes to TBP-class protein binding activity. Involved in RNA polymerase II preinitiation complex assembly. Part of transcription factor TFIIA complex. Orthologous to several human genes including GTF2A1 (general transcription factor IIA subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See TOA1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (711683..712543, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene tRNA-Met Neighboring gene Pex27p Neighboring gene Slk19p Neighboring gene putative lipoate synthase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Improved method for soluble expression and rapid purification of yeast TFIIA. Adachi N, et al. Protein Expr Purif, 2017 May. PMID 28259734
    2. TFIIA has activator-dependent and core promoter functions in vivo. Stargell LA, et al. J Biol Chem, 2000 Apr 28. PMID 10777519
    3. Transcriptional activation in yeast cells lacking transcription factor IIA. Chou S, et al. Genetics, 1999 Dec. PMID 10581267, Free PMC Article
    4. High-resolution mapping of nucleoprotein complexes by site-specific protein-DNA photocrosslinking: organization of the human TBP-TFIIA-TFIIB-DNA quaternary complex. Lagrange T, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855228, Free PMC Article
    5. Five intermediate complexes in transcription initiation by RNA polymerase II. Buratowski S, et al. Cell, 1989 Feb 24. PMID 2917366

    See all (85) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to TBP-class protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to TBP-class protein binding IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coregulator activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA polymerase II preinitiation complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIIA complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcription initiation factor IIA large subunit
    NP_014837.1
    • TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa2p, for ribosomal protein gene transcription in vivo; homologous to largest and second largest subunits of human and Drosophila TFIIA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      711683..712543 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183613.1 → NP_014837.1  TPA: transcription initiation factor IIA large subunit [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014837.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2Q3, E9P936, P32773
      UniProtKB/TrEMBL
      A0A6A5Q2T8, A6ZP40, B3LJM4, B5VS79, C7GWI5, C8ZGV3, G2WN69, N1P3D1
      Conserved Domains (1) summary
      cl21683
      Location:1 → 286
      TFIIA_alpha_beta_like; Precursor of TFIIA alpha and beta subunits and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32773.1

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