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    ANB1 translation elongation factor eIF-5A [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853506, updated on 17-May-2024

    Summary

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    Gene symbol
    ANB1
    Gene description
    translation elongation factor eIF-5A
    Primary source
    FungiDB:YJR047C
    Locus tag
    YJR047C
    See related
    SGD:S000003808; AllianceGenome:SGD:S000003808
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HYP1; TIF51B
    Summary
    Predicted to enable ribosome binding activity and translation elongation factor activity. Involved in positive regulation of translational elongation and translational frameshifting. Located in cytosolic ribosome. Orthologous to several human genes including EIF5A (eukaryotic translation initiation factor 5A) and EIF5A2 (eukaryotic translation initiation factor 5A2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ANB1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (524908..525381, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Tah11p Neighboring gene tRNA-Ser Neighboring gene cytochrome c isoform 1 Neighboring gene NADH/NAD(+) kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxygen regulation of anaerobic and aerobic genes mediated by a common factor in yeast. Lowry CV, et al. Proc Natl Acad Sci U S A, 1984 Oct. PMID 6385009, Free PMC Article
    2. Identification of an upstream repressor site controlling the expression of an anaerobic gene (ANB1) in Saccharomyces cerevisiae. Mehta KD, et al. J Biol Chem, 1989 May 25. PMID 2656688
    3. The ANB1 locus of Saccharomyces cerevisiae encodes the protein synthesis initiation factor eIF-4D. Mehta KD, et al. J Biol Chem, 1990 May 25. PMID 2187871
    4. In vitro yeast reconstituted translation system reveals function of eIF5A for synthesis of long polypeptide. Abe T, et al. J Biochem, 2020 May 1. PMID 32053170
    5. Crystal Structure of Hypusine-Containing Translation Factor eIF5A Bound to a Rotated Eukaryotic Ribosome. Melnikov S, et al. J Mol Biol, 2016 Sep 11. PMID 27196944, Free PMC Article

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vitro yeast reconstituted translation system reveals function of eIF5A for synthesis of long polypeptide.
      Title: In vitro yeast reconstituted translation system reveals function of eIF5A for synthesis of long polypeptide.
    2. results link eIF5A function in translation with a role of signal recognition particle in the cell and may help explain the dual effects of eIF5A in differential and general translation
      Title: eIF5A has a function in the cotranslational translocation of proteins into the ER.
    3. Eukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae.
      Title: Eukaryotic translation initiation factor (eIF) 5A stimulates protein synthesis in Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables translation elongation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation elongation factor activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translational elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of translational termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of translational termination ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational frameshifting IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosolic ribosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    translation elongation factor eIF-5A
    NP_012581.3
    • Translation elongation factor eIF-5A; previously thought to function in translation initiation; undergoes an essential hypusination modification; expressed under anaerobic conditions; ANB1 has a paralog, HYP2, that arose from the whole genome duplication; human EIF5A complements the inviability of the yeast hyp2 anb1 double null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      524908..525381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181705.3 → NP_012581.3  TPA: translation elongation factor eIF-5A [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012581.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWL8, P19211
      UniProtKB/TrEMBL
      A0A6A5PV65, A6ZQ06, B3LQD6, D3UF95, G2WCJ9, G2WH52, N1P131
      Conserved Domains (1) summary
      cl30809
      Location:1 → 154
      PLN03107; eukaryotic translation initiation factor 5A; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P19211.3

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