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    KHA1 Kha1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853351, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KHA1
    Official Full Name
    Kha1p
    Primary source
    SGD:S000003630
    Locus tag
    YJL094C
    See related
    AllianceGenome:SGD:S000003630; FungiDB:YJL094C; VEuPathDB:YJL094C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables potassium:proton antiporter activity. Involved in inorganic cation transmembrane transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See KHA1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (251821..254442, complement)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene mitochondrial 54S ribosomal protein YmL49 Neighboring gene mitogen-activated protein kinase kinase kinase BCK1 Neighboring gene Tok1p Neighboring gene DNA helicase SRS2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The functioning of mammalian ClC-2 chloride channel in Saccharomyces cerevisiae cells requires an increased level of Kha1p. Flis K, et al. Biochem J, 2005 Sep 15. PMID 15926887, Free PMC Article
    2. A Saccharomyces cerevisiae mutant lacking a K+/H+ exchanger. Ramírez J, et al. J Bacteriol, 1998 Nov. PMID 9811642, Free PMC Article
    3. Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase. Wu X, et al. J Biol Chem, 2016 Apr 29. PMID 26966178, Free PMC Article
    4. Arabidopsis thaliana CHX17 gene complements the kha1 deletion phenotypes in Saccharomyces cerevisiae. Maresova L, et al. Yeast, 2006 Dec. PMID 17133624
    5. Exploration of yeast alkali metal cation/H+ antiporters: sequence and structure comparison. Pribylová L, et al. Folia Microbiol (Praha), 2006. PMID 17176761

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study reveals a novel functional role of K(+) in the binding of copper to apoFet3p and identifies a K(+)/H(+) exchanger at the secretory pathway as a new molecular factor associated with iron uptake in yeast.
      Title: Potassium and the K+/H+ Exchanger Kha1p Promote Binding of Copper to ApoFet3p Multi-copper Ferroxidase.
    2. The authors conclude that Arl1p, Kha1p and Nhx1p collaborate in survival strategies at nonoptimal pH, temperatures and cation concentrations, but work independent of each other.
      Title: Genetic interactions among the Arl1 GTPase and intracellular Na(+) /H(+) antiporters in pH homeostasis and cation detoxification.
    3. important for the regulation of intracellular cation homeostasis and optimal pH control
      Title: Physiological characterization of Saccharomyces cerevisiae kha1 deletion mutants.
    4. Yeast Kha1 proteins probably belong to the same subfamily as bacterial antiporters, whereas Nhal proteins form a distinct subfamily
      Title: Exploration of yeast alkali metal cation/H+ antiporters: sequence and structure comparison.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antiporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic cation transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables potassium:proton antiporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in inorganic cation transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    Kha1p
    NP_012441.1
    • Putative K+/H+ antiporter; involved in intracellular cation homeostasis; promotes copper binding to Fet3p multicopper oxidase; localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      251821..254442 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181527.1 → NP_012441.1  TPA: Kha1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012441.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW90, P40309
      UniProtKB/TrEMBL
      C8ZBB9, N1P0T3
      Conserved Domains (1) summary
      PLN03159
      Location:1 → 433
      PLN03159; cation/H(+) antiporter 15; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40309.1

    Gene LinkOut

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